Toll-like receptor 9 polymorphisms and Hepatitis B virus clearance in Moroccan chronic carriers

被引：12

作者：

Chihab, Hajar ^{[1
,2
]}

Zaidane, Imane ^{[1
]}

Elhabazi, Abdellah ^{[2
]}

Jadid, Fatima-Zahra ^{[1
]}

El Fihri, Raouia ^{[1
]}

Elmessaoudi-Idrissi, Mohcine ^{[1
]}

Chair, Mohammed ^{[2
]}

Badre, Wafaa ^{[3
]}

Tahiri, Mohamed ^{[3
]}

Pineau, Pascal ^{[4
]}

Chemin, Isabelle ^{[5
]}

Ezzikouri, Sayeh ^{[1
]}

Benjelloun, Soumaya ^{[1
]}

机构：

[1] Inst Pasteur Maroc, Viral Hepatitis Lab, Virol Unit, 1 Pl Louis Pasteur, Casablanca 20360, Morocco

[2] Univ Chouaib Doukkali, Fac Sci Jadida, Lab Biotechnol Biochim & Nutr, El Jadida 24000, Morocco

[3] CHU Ibn Rochd, Fac Med Casablanca, Casablanca, Morocco

[4] Inst Pasteur, INSERM, U993, Unite Org Nucl & Oncogenese, Paris, France

[5] Lyon Univ Claude Bernard, Ctr Rech Cancerol, CNRS, UMR5286,INSERM,U1052, Lyon, France

来源：

GENE | 2019年 / 687卷

关键词：

TLR9; Polymorphisms; HBV clearance; IFN;

D O I：

10.1016/j.gene.2018.11.041

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Objectives: Toll-like receptor 9 (TLR9) plays a crucial role in the innate immune response against viral infections. The failure of this system may result, in an attenuated immune response against HBV. Recent research has focused on the possibility of targeting the defects in TLR9 pathway as a novel approach for anti-HBV treatment. Our study aimed to assess the impact of both TLR9 rs5743836 and rs187084 polymorphisms on spontaneous HBV clearance in Moroccan chronic HBV carriers. Methods: In this study, 239 individuals chronically infected with HBV (CHB) and 133 subjects who spontaneously resolved the infection (SRB) were genotyped using a Taqman allelic discrimination assay. Results/conclusion: Remarkably, we observed a dosage effect of both SNPs on viral loads; with a significant increase of circulating HBV DNA within AA, AG to GG rs5743836 genotypes, whereas the inverse phenomenon was noticed within rs187084 genotypes. There were no consistent association between TLR9 polymorphisms and spontaneous clearance of HBV, however, a significant association was observed between rs187084 AA genotype and HBV progression to advanced liver disease. Further studies on larger populations might be necessary to understand the modulating effect of TLR9 polymorphisms on HBV loads that remain a viral factor of paramount importance to predict HCC development.

引用

页码：212 / 218

页数：7

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