Design and synthesis of potential inhibitors of multienzyme systems included in Alzheimer's disease

被引：0

作者：

Ivanov, I. ^{[1
]}

Vezenkov, L. ^{[1
]}

Danalev, D. ^{[2
]}

机构：

[1] Univ Chem Technol & Met, Dept Organ Chem, Sofia 1756, Bulgaria

[2] Univ Chem Technol & Met, Dept Biotechnol, Sofia 1756, Bulgaria

来源：

BULGARIAN CHEMICAL COMMUNICATIONS | 2015年 / 47卷 / 02期

关键词：

OM99-2; analogues; Alzheimer's disease; inhibitors of multienzyme systems;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of a series of 6 peptides, potential inhibitors of p-secretase, analogues of the P-secretase inhibitor OM99-2 was designed and performed. Standard peptide synthesis in solution was applied by stepwise addition of amino acids from C- to N-terminus. All reactions gave very good yields (higher than 80%).

引用

页码：531 / 534

页数：4

共 7 条

[1] Inhibitors of Serine Proteinases from Blood Coagulation Cascade - View on Current Developments
Danalev, D.
[J]. MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2012, 12 (08) : 721 - 730
[2] Findrik Z, 2009, CHEM BIOCHEM ENG Q, V23, P545, DOI 10.1081/E-ECHP-120017565
[3] Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)
Ghosh, AK
Devasamudram, T
Hong, L
DeZutter, C
Xu, XM
Weerasena, V
Koelsch, G
Bilcer, G
Tang, J
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (01) : 15 - 20
[4] AMYLOID DEPOSITION AS THE CENTRAL EVENT IN THE ETIOLOGY OF ALZHEIMERS-DISEASE
HARDY, J
ALLSOP, D
[J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (10) : 383 - 388
[5] Alzheimer's disease - do tauists and baptists finally shake hands?
Mudher, A
Lovestone, S
[J]. TRENDS IN NEUROSCIENCES, 2002, 25 (01) : 22 - 26
[6] RETRACTED: APP binds DR6 to trigger axon pruning and neuron death via distinct caspases (Retracted Article)
Nikolaev, Anatoly
McLaughlin, Todd
O'Leary, Dennis D. M.
Tessier-Lavigne, Marc
[J]. NATURE, 2009, 457 (7232) : 981 - U1
[7] Design of substrate-based inhibitors of human β-secretase
Tung, JS
Davis, DL
Anderson, JP
Walker, DE
Mamo, S
Jewett, N
Hom, RK
Sinha, S
Thorsett, ED
John, V
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (02) : 259 - 262

← 1 →