microRNA in inflammatory bowel disease at a glance

被引：12

作者：

Alamdari-Palangi, Vahab ^{[1
]}

Vahedi, Farzaneh ^{[2
]}

Shabaninejad, Zahra ^{[3
,4
]}

Dokeneheifard, Sadat ^{[3
,5
]}

Movehedpour, Ahmad ^{[2
,6
]}

Taheri-Anganeh, Mortaza ^{[7
]}

Savardashtaki, Amir ^{[2
,3
]}

机构：

[1] Arak Univ Med Sci, Fac Med, Dept Mol Med & Biotechnol, Arak, Iran

[2] Shiraz Univ Med Sci, Dept Med Biotechnol, Sch Adv Med Sci & Technol, Shiraz, Iran

[3] Shiraz Univ Med Sci, Pharmaceut Sci Res Ctr, Shiraz, Iran

[4] Tarbiat Modares Univ, Fac Biol Sci, Dept Nanobiotechnol, Tehran, Iran

[5] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Dept Human Genet, Miami, FL 33136 USA

[6] Shiraz Univ Med Sci, Student Res Comm, Shiraz, Iran

[7] Urmia Univ Med Sci, Cellular & Mol Res Ctr, Res Inst Cellular & Mol Med, Orumiyeh, Iran

来源：

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | 2021年 / 33卷 / 02期

关键词：

Crohn's disease; inflammatory bowel disease; miRNA; ulcerative colitis; NF-KAPPA-B; NOD-LIKE RECEPTORS; ULCERATIVE-COLITIS; NUCLEAR EXPORT; CIRCULATING MICRORNAS; IMMUNE-RESPONSES; CROHNS-DISEASE; HOST-DEFENSE; SMALL RNAS; EXPRESSION;

D O I：

10.1097/MEG.0000000000001815

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Inflammatory bowel disease (IBD) as a chronic inflammation in colon and small intestine has two subtypes: ulcerative colitis (UC) and Crohn's disease (CD). Genome studies have shown that UC and CD are related to microRNAs (miRNAs) expression in addition to environmental factors. This article reviews important researches that have recently been done on miRNAs roles in CD and UC disease. First, miRNA is introduced and its biogenesis and function are discussed. Afterward, roles of miRNAs in inflammatory processes involved in IBD are showed. Finally, this review proposes some circulating and tissue-specific miRNAs, which are useful for CD and UC fast diagnosis and grade prediction. As a conclusion, miRNAs are efficient diagnostic molecules especially in IBD subtypes discrimination and can be used by microarray and real time PCR methods for disease detection and classification. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：140 / 148

页数：9

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