Rh-Catalyzed Construction of Quinolin-2(1H)-ones via C-H Bond Activation of Simple Anilines with CO and Alkynes

被引：130

作者：

Li, Xinyao ^{[1
]}

Li, Xinwei ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 29期

基金：

中国国家自然科学基金;

关键词：

ONE-POT SYNTHESIS; INTERNAL ALKYNES; OXIDATIVE CARBONYLATION; REGIOSELECTIVE CARBONYLATION; SELECTIVE ACTIVATION; EFFICIENT SYNTHESIS; MOLECULAR-OXYGEN; C(SP(3))-H BONDS; ANNULATION; RUTHENIUM;

D O I：

10.1021/jacs.5b05843

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and efficient Rh-catalyzed Carbonylation and annulation of simple anilines with CO and alkynes through N-H and CH bond activation for the direct synthesis of quinolin-2(1H)-ones has been developed. Simple anilines without preactivation, broad substrate scope with hetero/polycycles, and high-value products make this protocol very-practical and attractive. A key rhodacycle complex was isolated and well-characterized.

引用

页码：9246 / 9249

页数：4

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