Direct amination of pyrimidin-2-yl tosylates with aqueous ammonia under metal-free and mild conditions

被引：2

作者：

Gong, Hai-Peng ^{[1
]}

Zhang, Yue ^{[1
]}

Da, Yu-Xia ^{[1
]}

Zhang, Zhang ^{[1
]}

Quan, Zheng-Jun ^{[1
]}

Wang, Xi-Cun ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chern Engn, Lab Ecoenvironm Related Polymer Mat, Minist Educ,Gansu Key Lab Polymer Mat, Lanzhou 730070, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 06期

关键词：

Ammonia; 2-Aminopyrimidines; Pyrimidin-2-yl tosylate; PEG-400; BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS; COPPER-CATALYZED AMINATION; ONE-POT SYNTHESIS; ARYL HALIDES; REDUCTIVE AMINATION; PRIMARY AMINES; PRIMARY ARYLAMINES; DERIVATIVES; HYDROAMINATION; EFFICIENT;

D O I：

10.1016/j.cclet.2015.01.034

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free synthesis of pyrimidine functionalized primary amines via direct amination of pyrimidin-2-yl tosylate with aqueous ammonia has been developed under mild conditions. The desired products pyrimidin-2-amines can be generated in excellent yields in PEG-400, without any catalysts or other additives. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：667 / 671

页数：5

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