Predictive Strength of Photophysical Measurements for in Vitro Photobiological Activity in a Series of Ru(II) Polypyridyl Complexes Derived from π-Extended Ligands

被引：29

作者：

Reichardt, Christian ^{[1
,2
,5
]}

Monro, Susan ^{[6
]}

Sobotta, Fabian H. ^{[3
,4
]}

Colon, Katsuya L. ^{[7
]}

Sainuddin, Tariq ^{[6
]}

Stephenson, Mat ^{[6
]}

Sampson, Eric ^{[6
]}

Roque, John, III ^{[7
]}

Yin, Huimin ^{[6
]}

Brendel, Johannes C. ^{[3
,4
]}

Cameron, Cohn G. ^{[7
]}

McFarland, Sherri ^{[6
,7
]}

Dietzek, Benjamin ^{[1
,2
,5
]}

机构：

[1] Friedrich Schiller Univ Jena, Inst Phys Chem, D-07743 Jena, Germany

[2] Friedrich Schiller Univ Jena, Abbe Ctr Photon, D-07743 Jena, Germany

[3] Friedrich Schiller Univ Jena, Lab Organ & Macromol Chem IOMC, D-07743 Jena, Germany

[4] Friedrich Schiller Univ Jena, JCSM, D-07743 Jena, Germany

[5] Leibniz Inst Photon Technol IPHT Jena, Dept Funct Interfaces, Albert Einstein Str 9, D-07745 Jena, Germany

[6] Acadia Univ, Dept Chem, Wolfville, NS B4P 2R6, Canada

[7] Univ N Carolina, Dept Chem & Biochem, Greensboro, NC 27402 USA

来源：

INORGANIC CHEMISTRY | 2019年 / 58卷 / 05期

基金：

美国国家卫生研究院; 加拿大健康研究院;

关键词：

TRIPLET ENERGY-TRANSFER; EXCITED-STATE DYNAMICS; RUTHENIUM(II) COMPLEXES; PHOTODYNAMIC THERAPY; ELECTRONIC-SPECTRUM; SINGLET-OXYGEN; METAL; PHOTOSENSITIZERS; PHOTOCHEMISTRY; DYADS;

D O I：

10.1021/acs.inorgchem.8b03223

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This study investigates the correlation between photocytotoxicity and the prolonged excited-state lifetimes exhibited by certain Ru(II) polypyridyl photosensitizers comprised of pi-expansive ligands. The eight metal complexes selected for this study differ markedly in their triplet state configurations and lifetimes. Human melanoma SKMEL28 and human leukemia HL60 cells were used as in vitro models to test photocytotoxicity induced by the compounds when activated by either broadband visible or monochromatic red light. The photocytotoxicities of the metal complexes investigated varied over 2 orders of magnitude and were positively correlated with their excited-state lifetimes. The complexes with the longest excited-state lifetimes, contributed by low-lying (IL)-I-3 states, were the most phototoxic toward cancer cells under all conditions.

引用

页码：3156 / 3166

页数：11

共 16 条

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