Evaluation of the reducing power effect on the enantioselective synthesis of methyl (R)-2-chloromandelate using Saccharomyces cerevisiae

被引：0
|
作者：
Jeong, Min [1 ]
Yoo, Ik-keun [1 ]
Han, Mee Jung [2 ]
Hong, Soon Ho [1 ]
机构：
[1] Univ Ulsan, Dept Chem Engn & Bioengn, Ulsan 680749, South Korea
[2] Dongyang Univ, Sch Chem & Biomol Engn, Pungki Eup 750711, Youngju, South Korea
来源：
KOREAN JOURNAL OF CHEMICAL ENGINEERING | 2011年 / 28卷 / 12期
关键词：
Asymmetric Reduction; Reducing Power; Methyl (R)-2-Chloromandelate; Saccharomyces cerevisiae; ASYMMETRIC REDUCTION; BICYCLIC DIKETONE; ESCHERICHIA-COLI; BIOCATALYSIS; DRUGS;
D O I：
10.1007/s11814-011-0124-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effect of the reducing power on the reduction of methyl-2-chlorobenzoylformate was evaluated by using carbon substrates with different reducing powers. Glucose, sorbitol, and gluconate regenerated 2, 3, and 1 NAD(P)H during its conversion to pyruvate, respectively. When sorbitol was used as the carbon substrate, complete conversion was achieved in 8 h while it took 12 h and 19 h when glucose and gluconate were used, respectively. The enantiomeric excess (ee) value was 96.7% when sorbitol was used.
引用
收藏
页码：2316 / 2318
页数：3
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