Evaluation of the reducing power effect on the enantioselective synthesis of methyl (R)-2-chloromandelate using Saccharomyces cerevisiae

被引：0
|
作者：
Jeong, Min [1 ]
Yoo, Ik-keun [1 ]
Han, Mee Jung [2 ]
Hong, Soon Ho [1 ]
机构：
[1] Univ Ulsan, Dept Chem Engn & Bioengn, Ulsan 680749, South Korea
[2] Dongyang Univ, Sch Chem & Biomol Engn, Pungki Eup 750711, Youngju, South Korea
来源：
KOREAN JOURNAL OF CHEMICAL ENGINEERING | 2011年 / 28卷 / 12期
关键词：
Asymmetric Reduction; Reducing Power; Methyl (R)-2-Chloromandelate; Saccharomyces cerevisiae; ASYMMETRIC REDUCTION; BICYCLIC DIKETONE; ESCHERICHIA-COLI; BIOCATALYSIS; DRUGS;
D O I：
10.1007/s11814-011-0124-3
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The effect of the reducing power on the reduction of methyl-2-chlorobenzoylformate was evaluated by using carbon substrates with different reducing powers. Glucose, sorbitol, and gluconate regenerated 2, 3, and 1 NAD(P)H during its conversion to pyruvate, respectively. When sorbitol was used as the carbon substrate, complete conversion was achieved in 8 h while it took 12 h and 19 h when glucose and gluconate were used, respectively. The enantiomeric excess (ee) value was 96.7% when sorbitol was used.
引用
收藏
页码：2316 / 2318
页数：3
相关论文
共 50 条
  • [1] Evaluation of the reducing power effect on the enantioselective synthesis of methyl (R)-2-chloromandelate using Saccharomyces cerevisiae
    Min Jeong
    Ik-keun Yoo
    Mee Jung Han
    Soon Ho Hong
    Korean Journal of Chemical Engineering, 2011, 28 : 2316 - 2318
  • [2] Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae
    Min Jeong
    Yoon Mi Lee
    Soon Ho Hong
    Sung Young Park
    Ik-keun Yoo
    Mee Jung Han
    Biotechnology Letters, 2010, 32 : 1529 - 1531
  • [3] Optimization of enantioselective synthesis of methyl (R)-2-chloromandelate by whole cells of Saccharomyces cerevisiae
    Jeong, Min
    Lee, Yoon Mi
    Hong, Soon Ho
    Park, Sung Young
    Yoo, Ik-keun
    Han, Mee Jung
    BIOTECHNOLOGY LETTERS, 2010, 32 (10) : 1529 - 1531
  • [4] Enantioselective resolution of methyl 2-chloromandelate by Candida antarctica lipase A in a solvent-free transesterification reaction
    Uhm, Ki-Nam
    Lee, Sang-Joon
    Kim, Hyung-kwoun
    Kang, Han-Young
    Lee, Younghoon
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2007, 45 (1-2) : 34 - 38
  • [5] Kinetic resolution of (R,S)-ethyl 2-chloromandelate in biphasic media using hydrolase of Klebsiella oxytoca
    Wang, Pei-Yun
    Chen, Teh-Liang
    Tsai, Shau-Wei
    ENZYME AND MICROBIAL TECHNOLOGY, 2006, 39 (04) : 930 - 935
  • [6] Enantioselective Synthesis of Vicinal (R,R)-Diols by Saccharomyces cerevisiae Butanediol Dehydrogenase
    Calam, Eduard
    Gonzalez-Roca, Eva
    Rosario Fernandez, M.
    Dequin, Sylvie
    Pares, Xavier
    Virgili, Albert
    Biosca, Josep A.
    APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2016, 82 (06) : 1706 - 1721
  • [7] Ru-catalyzed enantioselective preparation of methyl (R)-o-chloromandelate and its application in the synthesis of (S)-Clopidogrel
    Yin, Lu
    Shan, Wenjun
    Jia, Xian
    Li, Xingshu
    Chan, Albert S. C.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2009, 694 (13) : 2092 - 2095
  • [8] Highly enantioselective and efficient synthesis of methyl (R)-o-chloromandelate with recombinant E-coli:: toward practical and green access to clopidogrel
    Ema, Tadashi
    Okita, Nobuyasu
    Ide, Sayaka
    Sakai, Takashi
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, 5 (08) : 1175 - 1176
  • [9] Evaluation of the Saccharomyces cerevisiae ADH2 promoter for protein synthesis
    Lee, KM
    DaSilva, NA
    YEAST, 2005, 22 (06) : 431 - 440
  • [10] The enantioselective synthesis of (R)-(+)-6-isopropenyl-3-methyl-2-cycloheptenone
    Brocksom, Timothy J.
    Brocksom, Ursula
    Barbosa, Fernanda P.
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 2006, 17 (04) : 792 - 796
12345