Synthesis of [5,6]-fused pyridocoumarins through aza-Claisen rearrangement of 6-propargylaminocoumarins

被引：35

作者：

Symeonidis, Theodoros S. ^{[1
]}

Kallitsakis, Michael G. ^{[1
]}

Litinas, Konstantinos E. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Chem, Organ Chem Lab, Thessaloniki 54124, Greece

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 42期

关键词：

Pyrido[5,6]coumarins; MW irradiation; Propargylation; 7,8]-Fused pyrido[5,6]coumarins; Claisen rearrangement; REGIOSELECTIVE SYNTHESIS; AMINO-CLAISEN; DERIVATIVES; COUMARINS; HETEROCYCLES; CYCLIZATION; ENAMINES;

D O I：

10.1016/j.tetlet.2011.08.012

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[5,6]-Fused pyridocoumarins are prepared through aza-Claisen rearrangement and subsequent in situ cyclization of 6-propargylaminocoumarins under microwave irradiation in the presence of boron trifluoride diethyl etherate in N,N-dimethylformamide. During this process demethoxycarbonylation is observed in the corresponding 4-carbomethoxycoumarin derivatives. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5452 / 5455

页数：4

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