Synthesis and synthetic applications of 1-(3-O-tosyl-β-D-glucopyranosyl) thymines:: toward new classes of hexopyranosyl pyrimidines

被引：6

作者：

Deshpande, SG

Pathak, T ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kharagpur 721302, W Bengal, India

[2] Natl Chem Lab, Organ Chem Div Synth, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 10期

关键词：

hexopyranosyl; nucleosides; modified; allopyranosyl; altropyranosyl; azidonucleosides; thionucleosides; aminonucleosides;

D O I：

10.1016/j.tetlet.2003.12.153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

1-(2,4,6-Tri-O-acetyl-3-O-tosyl-beta-D-glucopyranosyl) thymine has been synthesized by combining thymine with the appropriate carbohydrate. The availability of this key nucleoside made possible the synthesis of 2,2'-O-anhydro-(4,6-O-phenyl- methylene-beta-D-altropyranosyl) thymine and 1-(2,3-O-anhydro-4,6-O-phenylmethylene-beta-D-mannopyranosyl) thymine. A wide range of modified hexopyranosyl nucleosides can be easily prepared from these functionalized starting materials. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：2255 / 2258

页数：4

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