Synthesis and antioxidant properties of some novel benzimidazole derivatives on lipid peroxidation in the rat liver

被引：116

作者：

Kus, C

Ayhan-Kilcigil, G ^{[1
]}

Eke, BC

Iscan, M

机构：

[1] Ankara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey

[2] Ankara Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2004年 / 27卷 / 02期

关键词：

thiosemicarbazides; thiadiazolylmethylbenzimidazoles; triazolylbenzimidazoles; antioxidant;

D O I：

10.1007/BF02980099

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Some benzimidazole derivatives namely 1-[(substituted thiocarbamoylhydrazine carbonyl) methyl]-2-phenyl-1H-benzimidazoles (1a-13a), N-[(2-phenylbenzimidazol-1-yl methyl)-[1,3,4]thiadiazole-2-yl]-substituted phenyl amines (1b-13b) and 5-(2-phenyl benzimidazol-1-yimethyl)-4-substituted phenyl-4H-1,2,4-triazole-3-thiones (11c-13c) were synthesized, and their in vitro effects on the rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels were determined. The most active compound 10a caused an 84% inhibition of LP at 10(-3) M, which is better than that of butylated hydroxytoluene (BHT) (65%).

引用

页码：156 / 163

页数：8

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