Molecular characterization of a feline calicivirus isolated from tiger and its pathogenesis in cats

被引：28

作者：

Tian, Jin ^{[1
]}

Liu, Dafei ^{[1
]}

Liu, Yongxiang ^{[1
]}

Wu, Hongxia ^{[1
]}

Jiang, Yanmei ^{[1
,3
]}

Zu, Shaopo ^{[1
,2
]}

Liu, Chunguo ^{[1
]}

Sun, Xue ^{[1
,2
]}

Liu, Jiasen ^{[1
]}

Qu, Liandong ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Harbin Vet Res Inst, State Key Lab Vet Biotechnol, Div Zoonosis Nat Foci, Harbin, Peoples R China

[2] Northeast Agr Univ, Coll Vet Med, Harbin, Peoples R China

[3] Heilongjiang Bayi Agr Univ, Coll Anim Sci & Vet Med, Daqing, Peoples R China

来源：

VETERINARY MICROBIOLOGY | 2016年 / 192卷

基金：

中国国家自然科学基金;

关键词：

Feline calicivirus; Siberian tiger; Phylogenetic analysis; Challenge experiments; GENETIC-ANALYSIS; INFECTION; NOROVIRUSES; GUIDELINES; OUTBREAK; TROPISM; DOGS;

D O I：

10.1016/j.vetmic.2016.07.005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Feline calicivirus (FCV) is a virus that causes respiratory disease in cats. In this study, the FCV TIG-1 was isolated from Siberian tiger feces collected in 2014 in Heilongjiang Province, China. Phylogenetic analysis among TIG-1 and other FCVs showed that TIG-1 does not share the same lineage with other FCV isolates from Heilongjiang or other regions in China but is located in the same cluster with the FCV strain Urbana, which was isolated from the United States. The growth kinetics in vitro and the pathogenicity in cats between TIG-1 and the domestic cat-origin FCV strain F9 (vaccine strain) and strain 2280 were compared. We found that the growth kinetics of strains TIG-1 and 2280 were faster than that of strain F9 from 12 h to 36h post-infection, indicating that strains TIG-1 and 2280 produce infectious virions and reach peak yields earlier. Challenge experiments in cats showed that TIG-1 grew faster than the other two strains in the lungs of cats and that TIG-1 is a virulent FCV with 100% morbidity and lethality. In addition, the histopathological results showed that the virulent TIG-1 strain directly led to severe lung tissue damage and indirectly led to intestinal damage. The results presented here show that a tiger-origin FCV exhibits high virulence in cats. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：110 / 117

页数：8

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