Scope of the organocatalysed asymmetric reductive amination of ketones with trichlorosilane

被引：40

作者：

Gautier, Francois-Moana ^{[1
]}

Jones, Simon ^{[1
]}

Li, Xianfu ^{[1
]}

Martin, Stephen J. ^{[2
]}

机构：

[1] Univ Sheffield, Dept Chem, Sheffield S3 7HF, S Yorkshire, England

[2] Aesica Pharmaceut Ltd, Cramlington NE23 3JL, Northd, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 22期

关键词：

N-ARYL IMINES; ENANTIOSELECTIVE HYDROGENATION; ORGANOLITHIUM REAGENTS; AMINES; KETIMINES; LIGANDS; ALKYLATION; COMPLEXES; ALDEHYDES; CATALYSTS;

D O I：

10.1039/c1ob05965c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly active organocatalyst has been shown to affect the asymmetric reductive amination of ketones producing both aromatic and aliphatic amines. At 1 mol% catalyst loading, a series of structurally diverse chiral amines were quickly and economically prepared with good enantioselectivity and generally useful yield. The efficient synthesis of the calcimimetic (+)-NPS R-568 (67%, 89% ee) demonstrated the synthetic applicability of this methodology.

引用

页码：7860 / 7868

页数：9

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