In vitro Studies of Graphene Oxide Reinforced Hydroxyapatite Nanobiocomposite on Human Erythrocytes

被引：4

作者：

Radha, G. ^{[1
]}

Vinod, Rohith K. ^{[1
]}

Venkatesan, Balaji ^{[2
]}

Vellaichamy, Elangovan ^{[2
]}

Balakumar, S. ^{[1
]}

机构：

[1] Univ Madras, Natl Ctr Nanosci & Nanotechnol, Guindy Campus, Madras 600025, Tamil Nadu, India

[2] Univ Madras, Dept Biochem, Guindy Campus, Madras 600025, Tamil Nadu, India

来源：

61ST DAE-SOLID STATE PHYSICS SYMPOSIUM | 2017年 / 1832卷

关键词：

Graphene oxide; Nano-hydroxyapatite; Hemocompatibility; Erythrocytes;

D O I：

10.1063/1.4980360

中图分类号：

O469 [凝聚态物理学];

学科分类号：

070205 ;

摘要：

We report the interaction of graphene oxide reinforced hydroxyapatite (GO-HAp) nanocomposites with human erythrocytes. The hemocompatibility of GO-HAp found to be superior as compared to the pristine graphene oxide. It is found that the HAp nanoparticles on GO decrease the disruption of erythrocytes by minimizing the exposure of oxygen groups to phosphatidylcholine surface of erythrocyte membrane and it enhances hemocompatibility. Further, it is also found that the graphene oxide reinforced HAp nanobiocomposite enhances the metabolic activity of osteoblasts-like cells by promoting cell proliferation.

引用

页数：3

共 5 条

[1] The chemistry of graphene oxide [J].

Dreyer, Daniel R. ;

Park, Sungjin ;

Bielawski, Christopher W. ;

Ruoff, Rodney S. .

CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) :228-240

[2] Improved Synthesis of Graphene Oxide [J].

Marcano, Daniela C. ;

Kosynkin, Dmitry V. ;

Berlin, Jacob M. ;

Sinitskii, Alexander ;

Sun, Zhengzong ;

Slesarev, Alexander ;

Alemany, Lawrence B. ;

Lu, Wei ;

Tour, James M. .

ACS NANO, 2010, 4 (08) :4806-4814

[3] Evaluation of hemocompatibility and in vitro immersion on microwave-assisted hydroxyapatite-alumina nanocomposites [J].

Radha, G. ;

Balakumar, S. ;

Venkatesan, Balaji ;

Vellaichamy, Elangovan .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2015, 50 :143-150

[4] Highly biocompatible, nanocrystalline hydroxyapatite synthesized in a solvothermal process driven by high energy density microwave radiation [J].

Smolen, Dariusz ;

Chudoba, Tadeusz ;

Malka, Iwona ;

Kedzierska, Aleksandra ;

Lojkowski, Witold ;

Swieszkowski, Wojciech ;

Kurzydlowski, Krzysztof Jan ;

Kolodziejczyk-Mierzynska, Malgorzata ;

Lewandowska-Szumiel, Malgorzata .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2013, 8 :653-668

[5] Graphene and Graphene Oxide: Synthesis, Properties, and Applications [J].

Zhu, Yanwu ;

Murali, Shanthi ;

Cai, Weiwei ;

Li, Xuesong ;

Suk, Ji Won ;

Potts, Jeffrey R. ;

Ruoff, Rodney S. .

ADVANCED MATERIALS, 2010, 22 (35) :3906-3924

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