Histology-based Combination Induction Chemotherapy for Elderly Patients with Clinical Stage III Non-small Cell Lung Cancer

被引：4

作者：

Banna, Giuseppe L. ^{[1
]}

Parra, Hector Jose Soto ^{[4
]}

Castaing, Marine ^{[5
]}

Dieci, Maria Vittoria ^{[6
]}

Anile, Giuseppe ^{[6
]}

Nicolosi, Maurizio ^{[2
]}

Strano, Salvatore ^{[2
]}

Marletta, Francesco ^{[3
]}

Guarneri, Valentina ^{[6
]}

Conte, Pierfranco ^{[6
]}

Lal, Rohit ^{[7
]}

机构：

[1] Cannizzaro Hosp, Div Med Oncol, Via Messina 829, I-95126 Catania, Italy

[2] Cannizzaro Hosp, Div Thorac Surg, Catania, Italy

[3] Cannizzaro Hosp, Div Radiotherapy, Catania, Italy

[4] AOU Vittorio Emanuele Polyclin, Div Med Oncol, Catania, Italy

[5] Univ Catania, GF Ingrassia Dept, Catania, Italy

[6] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy

[7] Guys & St Thomas Hosp, Lung Canc Unit, London, England

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 07期

关键词：

Elderly; induction chemotherapy; non-small cell lung cancer; stage III; adenocarcinoma; squamous cell carcinoma; RADIATION-THERAPY; CARBOPLATIN;

D O I：

10.21873/anticanres.11745

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To explore the feasibility and activity of a histology-based induction combination chemotherapy for elderly patients with clinical stage III non-small cell lung cancer (NSCLC). Patients and Methods: Patients aged >= 70 years with stage IIIA and IIIB lung squamous cell carcinoma (SCC) or adenocarcinoma were treated with three cycles of carboplatin and gemcitabine or pemetrexed, respectively, followed by definitive radiotherapy or surgery. The primary endpoint was the overall response rate (ORR) following induction. Results: Twenty-seven patients, with a median age of 74 years (range=70-80 years) were treated for adenocarcinoma in 14 (52%) and SCC in 13 (48%), clinical stage IIIA in eight (30%) and IIIB in 19 (70%). Grade 3 or 4 toxicity was reported for five patients (18.5%). The ORR was 46% in 12 (partial responses) out of 26 assessable patients. Conclusion: Histology-based induction combination chemotherapy is active and feasible in elderly patients with stage III NSCLC.

引用

页码：3723 / 3728

页数：6

共 17 条

[1] Sample size tables for exact single-stage phase II designs [J].

A'Hern, RP .

STATISTICS IN MEDICINE, 2001, 20 (06) :859-866

[2]

Asami K, 2015, AUSTIN J CANC CLIN R, V2, P1043

[3] Thoracic radiotherapy with or without daily low-dose carboplatin in elderly patients with non-small-cell lung cancer: a randomised, controlled, phase 3 trial by the Japan Clinical Oncology Group (JCOG0301) [J].

Atagi, Shinji ;

Kawahara, Masaaki ;

Yokoyama, Akira ;

Okamoto, Hiroaki ;

Yamamoto, Nobuyuki ;

Ohe, Yuichiro ;

Sawa, Toshiyuki ;

Ishikura, Satoshi ;

Shibata, Taro ;

Fukuda, Haruhiko ;

Saijo, Nagahiro ;

Tamura, Tomohide .

LANCET ONCOLOGY, 2012, 13 (07) :671-678

[4] A three-drug induction chemotherapy with gemcitabine, carboplatin, and paclitaxel for stage III non-small cell lung cancer [J].

Banna, Giuseppe Luigi ;

Lipari, Helga ;

Nicolosi, Maurizio ;

Basile, Antonio ;

Fraggetta, Filippo ;

Vaglica, Marina ;

Marletta, Francesco ;

Urso, Orazio Ezio ;

Ippolito, Massimo ;

Terminella, Alberto ;

Saita, Salvatore .

MEDICAL ONCOLOGY, 2013, 30 (02)

[5] A review of the management of elderly patients with non-small-cell lung cancer [J].

Blanco, R. ;

Maestu, I. ;

de la Torre, M. G. ;

Cassinello, A. ;

Nunez, I. .

ANNALS OF ONCOLOGY, 2015, 26 (03) :451-463

[6]

COX DR, 1972, J R STAT SOC B, V34, P187

[7] New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) [J].

Eisenhauer, E. A. ;

Therasse, P. ;

Bogaerts, J. ;

Schwartz, L. H. ;

Sargent, D. ;

Ford, R. ;

Dancey, J. ;

Arbuck, S. ;

Gwyther, S. ;

Mooney, M. ;

Rubinstein, L. ;

Shankar, L. ;

Dodd, L. ;

Kaplan, R. ;

Lacombe, D. ;

Verweij, J. .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (02) :228-247

[8]

Goldstraw P, 2011, J THORAC ONCOL, V2, P706

[9] Cardiac toxicity in association with chemotherapy and radiation therapy in a large cohort of older patients with non-small-cell lung cancer [J].

Hardy, D. ;

Liu, C. -C. ;

Cormier, J. N. ;

Xia, R. ;

Du, X. L. .

ANNALS OF ONCOLOGY, 2010, 21 (09) :1825-1833

[10] High-dose radiation therapy for elderly patients with inoperable or unresectable non-small cell lung cancer [J].

Hayakawa, K ;

Mitsuhashi, N ;

Katano, S ;

Saito, Y ;

Nakayama, Y ;

Sakurai, H ;

Akimoto, T ;

Hasegawa, M ;

Yamakawa, M ;

Niibe, H .

LUNG CANCER, 2001, 32 (01) :81-88

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