Pre-stimulus alpha power affects vertex N2-P2 potentials evoked by noxious stimuli

被引:16
作者
Babiloni, Claudio [1 ,2 ,3 ]
Del Percio, Claudio [4 ,5 ]
Brancucci, Alfredo [6 ]
Capotosto, Paolo [6 ]
Le Pera, Domenica [7 ]
Marzano, Nicola [1 ,5 ]
Valeriani, Massimiliano [8 ]
Romani, Gian Luca [6 ]
Arendt-Nielsen, Lars [9 ]
Rossini, Paolo Maria [2 ,4 ]
机构
[1] Univ Roma La Sapienza, Sezione EEG Ad Alta Risoluzione, Dipartimento Fisiol Umana & Farmacol, I-00185 Rome, Italy
[2] Osped FBF Isola Tiberina, AFaR CRCCS, Rome, Italy
[3] San Raffaele Cassino, Cassino, FR, Italy
[4] IRCCS, S Giovanni Dio FBF, Brescia, Italy
[5] Ist Med Sci Sport, CONI Serv, Rome, Italy
[6] GD Annunzio Univ Fdn, Inst Adv Biomed Technol, Chieti, Italy
[7] Casa Cura San Raffaele Pisana, Rome, Italy
[8] IRCCS, Osp Pediat Bambino Gesu, Div Neurol, Rome, Italy
[9] Aalborg Univ, SMI, Human Brain Mapping & Cort Imaging Lab, Aalborg, Denmark
关键词
pre-stimulus alpha rhythms; laser evoked potentials (LEPs); noxious stimulation; CO2; laser; vertex N2-P2 complex;
D O I
10.1016/j.brainresbull.2007.09.009
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
It is well known that scalp potentials evoked by nonpainful visual and auditory stimuli are enhanced in amplitude when preceded by pre-stimulus low-amplitude alpha rhythms. This study tested the hypothesis that the same holds for the amplitude of vertex N2-P2 potentials evoked by brief noxious laser stimuli, an issue of interest for clinical perspective. EEG data were recorded in 10 subjects from 30 electrodes during laser noxious stimulation. The artifact-free vertex N2-P2 complex was spatially enhanced by surface Laplacian transformation. Pre-stimulus alpha power was computed at three alpha sub-bands according to subject's individual alpha frequency peak (i.e. about 6-8 Hz for alpha 1, 8-10 Hz for alpha 2 and 10-12 Hz for alpha 3 sub-band). Individual EEG single trials were divided in two sub-groups. The strong-alpha sub-group (high band power) included halfway of all EEG single trials, namely those having the highest pre-stimulus alpha power. Weak-alpha sub-group (low band power) included the remaining trials. Averaging procedure provided laser evoked potentials for both trial sub-groups. No significant effect was found for alpha I and alpha 2 sub-bands. Conversely, compared to strong-alpha 3 sub-group, weak-alpha 3 sub-group showed vertex N2-P2 potentials having significantly higher amplitude (p < 0.05). These results extend to the later phases of pain processing systems the notion that generation mechanisms of pre-stimulus alpha rhythms and (laser) evoked potentials are intrinsically related and subjected to fluctuating "noise". That "noise" could explain the trial-by-trial variability of laser evoked potentials and perception. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:581 / 590
页数:10
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