Synthesis of proline-modified analogues of the neuroprotective agent glycyl-L-prolyl-glutamic acid (GPE)

被引：38

作者：

Harris, PWR ^{[1
]}

Brimble, MA ^{[1
]}

Muir, VJ ^{[1
]}

Lai, MYH ^{[1
]}

Trotter, NS ^{[1
]}

Callis, DJ ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Neuren Pharmaceut Med Chem Grp, Auckland 1000, New Zealand

来源：

TETRAHEDRON | 2005年 / 61卷 / 42期

关键词：

proline; neuroprotective; peptide; peptidomimetic;

D O I：

10.1016/j.tet.2005.08.026

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of ten proline-modified analogues of the neuroprotective tripeptide GPE is described. Five of the analogues incorporate a proline residue with a hydrophobic group at C-2 and two further analogues have this side chain locked into a spirolactam ring system. The pyrrolidine ring was also modified by replacing the gamma-CH2 group with sulfur and/or incorporation of two methyl groups at C-5. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：10018 / 10035

页数：18

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