Innate lymphoid cells: A new paradigm in immunology

被引：646

作者：

Eberl, Gerard ^{[1
]}

Colonna, Marco ^{[2
]}

Di Santo, James P. ^{[3
]}

McKenzie, Andrew N. J. ^{[4
]}

机构：

[1] Inst Pasteur, Microenvironm & Immun Unit, F-75724 Paris, France

[2] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[3] Inst Pasteur, Innate Immun Unit, INSERM U668, F-75724 Paris, France

[4] MRC, Mol Biol Lab, Cambridge CB2 0QH, England

来源：

SCIENCE | 2015年 / 348卷 / 6237期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

ROR-GAMMA-T; NATURAL-KILLER-CELLS; TISSUE-INDUCER CELLS; NK CELLS; INTESTINAL HOMEOSTASIS; TYPE-2; IMMUNITY; RETINOIC-ACID; B-CELL; LUNG INFLAMMATION; INTERFERON-GAMMA;

D O I：

10.1126/science.aaa6566

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Innate lymphoid cells (ILCs) are a growing family of immune cells that mirror the phenotypes and functions of T cells. However, in contrast to T cells, ILCs do not express acquired antigen receptors or undergo clonal selection and expansion when stimulated. Instead, ILCs react promptly to signals from infected or injured tissues and produce an array of secreted proteins termed cytokines that direct the developing immune response into one that is adapted to the original insult. The complex cross-talk between microenvironment, ILCs, and adaptive immunity remains to be fully deciphered. Only by understanding these complex regulatory networks can the power of ILCs be controlled or unleashed in order to regulate or enhance immune responses in disease prevention and therapy.

引用

页数：9

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