Acceptorless Dehydrogenative Cyclization of o-Aminobenzyl Alcohols with Ketones to Quinolines in Water Catalyzed by Water Soluble Metal Ligand Bifunctional Catalyst [Cp*(6,6′-(OH)2bpy)(H2O)[OTf]2

被引：162

作者：

Wang, Rongzhou ^{[1
]}

Fan, Hongjun ^{[1
]}

Zhao, Wei ^{[1
]}

Li, Feng ^{[1
,2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Peoples R China

来源：

ORGANIC LETTERS | 2016年 / 18卷 / 15期

基金：

中国国家自然科学基金;

关键词：

FUNCTIONAL BIPYRIDONATE LIGAND; ASTERISK-IR COMPLEX; ONE-POT SYNTHESIS; IRIDIUM COMPLEX; 2-AMINOBENZYL ALCOHOL; N-HETEROCYCLES; POLYSUBSTITUTED QUINOLINES; NITROGEN-HETEROCYCLES; ACRIDONE ALKALOIDS; ALPHA-ALKYLATION;

D O I：

10.1021/acs.orglett.6b01518

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The strategy for acceptorless dehydrogenative cyclization of o-aminobenzyl alcohols with ketones to quinolines in water has been accomplished. In the presence of [Cp*Ir(6,6'-(OH)(2)bpy)(H2O)][OTf](2), a series of desirable products were obtained in high yields. Notably, this research exhibits the potential for the construction of heterocycles via acceptorless dehydrogenative reactions in water catalyzed by watersoluble metal ligand bifunctional catalysts.

引用

页码：3558 / 3561

页数：4

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