Two-Year Body Composition Analyses of Long-Lived GHR Null Mice

被引：111

作者：

Berryman, Darlene E. ^{[1
,2
]}

List, Edward O. ^{[2
]}

Palmer, Amanda J.

Chung, Min-Yu ^{[3
]}

Wright-Piekarski, Jacob ^{[2
]}

Lubbers, Ellen ^{[2
]}

O'Connor, Patrick ^{[4
]}

Okada, Shigeru ^{[2
,5
]}

Kopchick, John J. ^{[2
,4
]}

机构：

[1] Ohio Univ, Sch Human & Consumer Sci, Grover Ctr W324, Coll Hlth & Human Serv, Athens, OH 45701 USA

[2] Ohio Univ, Edison Biotechnol Inst, Athens, OH 45701 USA

[3] Univ Connecticut, Dept Nutr Sci, Storrs, CT USA

[4] Ohio Univ, Dept Biomed Sci, Athens, OH 45701 USA

[5] Ohio Univ, Dept Pediat, Coll Osteopath Med, Athens, OH 45701 USA

来源：

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES | 2010年 / 65卷 / 01期

关键词：

Body composition; Growth hormone; Obesity; Adipose depots; Gender differences; HORMONE RECEPTOR KNOCKOUT; AGE-RELATED-CHANGES; GROWTH-FACTOR-I; CALORIE-RESTRICTED MICE; LIFE-SPAN; LARON-SYNDROME; TARGETED DISRUPTION; SKELETAL-MUSCLE; GENE-EXPRESSION; ADIPOSE-TISSUE;

D O I：

10.1093/gerona/glp175

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Growth hormone receptor gene-disrupted (GHR-/-) mice exhibit increased life span and adipose tissue mass. Although this obese phenotype has been reported extensively for young adult male GHR-/- mice, data for females and for other ages in either gender are lacking. Thus, the purpose of this study was to evaluate body composition longitudinally in both male and female GHR-/- mice. Results show that GHR-/- mice have a greater percent fat mass with no significant difference in absolute fat mass throughout life. Lean mass shows an opposite trend with percent lean mass not significantly different between genotypes but absolute mass reduced in GHR-/- mice. Differences in body composition are more pronounced in male than in female mice, and both genders of GHR-/- mice show specific enlargement of the subcutaneous adipose depot. Along with previously published data, these results suggest a consistent and intriguing protective effect of excess fat mass in the subcutaneous region.

引用

页码：31 / 40

页数：10

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