Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome

被引:18
作者
Satrauskiene, Agne [1 ,2 ]
Navickas, Rokas [1 ,2 ]
Laucevicius, Aleksandras [1 ,2 ,3 ]
Krilavicius, Tomas [4 ,5 ]
Uzupyte, Ruta [4 ,5 ,6 ]
Zdanyte, Monika [7 ]
Ryliskyte, Ligita [1 ,2 ]
Jucevicene, Agne [1 ,2 ]
Holvoet, Paul [8 ]
机构
[1] Vilnius Univ, Fac Med, Inst Clin Med, Clin Cardiac & Vasc Dis, LT-08661 Vilnius, Lithuania
[2] Vilnius Univ Hosp, Ctr Cardiol & Angiol, Santaros Klin, LT-08410 Vilnius, Lithuania
[3] Ctr Innovat Med, Expt Prevent & Clin Med Dept, LT-08406 Vilnius, Lithuania
[4] Vytautas Magnus Univ, Informat Fac, LT-44248 Kaunas, Lithuania
[5] Baltic Inst Adv Technol, LT-01124 Vilnius, Lithuania
[6] Vilnius Univ, Fac Math & Informat, LT-03225 Vilnius, Lithuania
[7] Univ Tubingen, Dept Cardiol & Cardiovasc Med, D-72074 Tubingen, Germany
[8] Katholieke Univ Leuven, Dept Cardiovasc Sci, Expt Cardiol, B-3000 Leuven, Belgium
关键词
subclinical atherosclerosis; arterial markers; metabolic syndrome; miRs; diagnosis; CAROTID-ARTERY STIFFNESS; CIRCULATING MICRORNAS; CARDIOVASCULAR-DISEASE; MYOCARDIAL FIBROSIS; ENDOTHELIAL INFLAMMATION; LIPID-METABOLISM; ISCHEMIC-STROKE; WHOLE-BLOOD; EXPRESSION; RISK;
D O I
10.3390/ijerph18041483
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Previously, miR-1, miR-122, miR-126, miR-132, miR-133, and miR-370 were found to be related to coronary artery disease (CAD) progression. However, their relationship with subclinical atherosclerosis, especially in subjects with metabolic syndrome, is unknown. Therefore, our aim was to determine their relationship with arterial markers of subclinical atherosclerosis. Metabolic syndrome subjects (n = 182) with high cardiovascular risk but without overt cardiovascular disease (CVD) were recruited from the Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program. The ardio-ankle vascular index (CAVI), augmentation index normalized to a heart rate of 75 bpm (AIxHR75), aortic pulse wave velocity (AoPWV), and carotid artery stiffness were assessed. MicroRNAs (miRs) were analyzed in serum. Pearson correlation and a univariate linear regression t-test showed that miR-1, miR-133b, and miR-133a were negatively associated with CAVI mean, whereas miR-122 was positively associated. MiR-1, miR-133b and miR-133a, and miR-145 were negatively associated with AIxHR75. MiR-122 correlated negatively with AoPWV. In multivariate linear regression models, miR-133b and miR-122 predicted CAVImean, miR-133 predicted AIxHR75, and miR-122 predicted AoPWV. MiR-132 predicted right carotid artery stiffness, and miR-1 predicted left carotid artery stiffness. The addition of smoking to miR-133b and miR-122 enhanced the prediction of CAVI. Age and triglycerides enhanced the prediction of AoPWV by miR-122. A cluster of four miRs are related to subclinical atherosclerosis in subjects with metabolic syndrome. Combined, they may have a more substantial diagnostic or prognostic value than any single miR. Future follow-up studies are needed to establish their clinical relevance.
引用
收藏
页码:1 / 14
页数:14
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