Deciphering the molecular basis of venous thromboembolism: where are we and where should we go?

被引：12

作者：

Morange, Pierre-Emmanuel ^{[1
]}

Tregouet, David-Alexandre ^{[2
]}

机构：

[1] Univ Mediterranean, Fac Med, INSERM, UMR S626, Marseille, France

[2] Univ Paris 06, INSERM, UMR S937, Paris, France

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2010年 / 148卷 / 04期

关键词：

genetics of thrombosis and haemostasis; epidemiology; venous thrombosis; GENOME-WIDE ASSOCIATION; VON-WILLEBRAND-FACTOR; FACTOR-V-LEIDEN; ACTIVATABLE FIBRINOLYSIS INHIBITOR; QUANTITATIVE-TRAIT LOCUS; FACTOR PATHWAY INHIBITOR; COMMON GENETIC-VARIATION; COPY NUMBER VARIATION; FACTOR-XII GENE; RISK-FACTOR;

D O I：

10.1111/j.1365-2141.2009.07975.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Venous thromboembolism (VTE) is a frequent disease that has a major genetic component of risk. However, known identified genetic risk factors account for <30% of idiopathic (without any environmental origin) VTE cases. This article aims to review the lessons learnt during recent decades in the field of the genetics of VTE, describe the present state-of-art methods and discuss promising themes for finding new susceptibility loci.

引用

页码：495 / 506

页数：12

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