NHC-Mediated Stetter-Aldol and Imino-Stetter-Aldol Domino Cyclization to Naphthalen-1(2H)-ones and Isoquinolines

被引：9

作者：

Barman, Debabrata ^{[1
]}

Ghosh, Tanmoy ^{[1
]}

Show, Krishanu ^{[1
]}

Debnath, Sudipto ^{[1
]}

Ghosh, Tapas ^{[2
]}

Maiti, Dilip K. ^{[1
]}

机构：

[1] Univ Calcutta, Dept Chem, Kolkata 700009, India

[2] Maulana Abul Kalam Azad Univ Technol, Dept Appl Sci, Haringhata 741249, W Bengal, India

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 06期

关键词：

CATALYZED REACTIONS; ALDEHYDES; CARBENES; MICHAEL; ENALS;

D O I：

10.1021/acs.orglett.1c00337

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Heterocyclic carbene-catalyzed tandem Stetteraldol reaction of phthalaldehyde and alpha,beta-unsaturated ketimines has been developed to afford functionalized naphthalen-1(2H)-one derivatives as the formal [4+2] annulation product. Interestingly, the reaction of aldimines led to the formation of isoquinoline derivatives instead of the expected indanone derivatives as a [4+1] annulation product.

引用

页码：2178 / 2182

页数：5

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