NHC-Mediated Stetter-Aldol and Imino-Stetter-Aldol Domino Cyclization to Naphthalen-1(2H)-ones and Isoquinolines

被引：12
作者：
Barman, Debabrata [1 ]
Ghosh, Tanmoy [1 ]
Show, Krishanu [1 ]
Debnath, Sudipto [1 ]
Ghosh, Tapas [2 ]
Maiti, Dilip K. [1 ]
机构：
[1] Univ Calcutta, Dept Chem, Kolkata 700009, India
[2] Maulana Abul Kalam Azad Univ Technol, Dept Appl Sci, Haringhata 741249, W Bengal, India
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 06期
关键词：
CATALYZED REACTIONS; ALDEHYDES; CARBENES; MICHAEL; ENALS;
D O I：
10.1021/acs.orglett.1c00337
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
N-Heterocyclic carbene-catalyzed tandem Stetteraldol reaction of phthalaldehyde and alpha,beta-unsaturated ketimines has been developed to afford functionalized naphthalen-1(2H)-one derivatives as the formal [4+2] annulation product. Interestingly, the reaction of aldimines led to the formation of isoquinoline derivatives instead of the expected indanone derivatives as a [4+1] annulation product.
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收藏
页码：2178 / 2182
页数：5
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