Studies on a novel minor-groove targeting artificial nuclease: Synthesis and DNA binding behavior

被引：2

作者：

Yin Qiang ^{[1
]}

Zhang Zhen ^{[1
]}

Zhao Yu-fen ^{[1
]}

机构：

[1] Tsinghua Univ, Minist Educ, Dept Chem, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China

来源：

CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2007年 / 23卷 / 01期

基金：

中国国家自然科学基金;

关键词：

calf thymus DNA; polyamide; bioconjugate; UV-Vis spectroscopy; circular dichroism;

D O I：

10.1016/S1005-9040(07)60009-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nucleases play an important role in molecular biology, for example, in DNA sequencing. Synthetic polyamide conjugates can be considered as a novel tool for the selective inhibition of gene expressions and also as potential drugs in anticancer or antiviral chemotherapy. In this article, the synthesis of a novel minor-groove targeting artificial nuclease, an oligopyrrol-containing compound, has been reported. It was found that this novel compound can bind DNA in AT-rich minor groove with high affinity and site specificity. DNA binding behavior was determined by using UV-Vis and CD. It is indicated that compound 6 can enhance the T of DNA from 80.4 degrees C to 84.4 degrees C and that it possesses a high binding constant value(Kb = 3.05 x 10(4) L/mol)

引用

页码：44 / 47

页数：4

共 50 条

[41] Facile synthesis of chalcone derivatives as antibacterial agents: Synthesis, DNA binding, molecular docking, DFT and antioxidant studies
Arif, Rizwan
Rana, Manish
Yasmeen, Shama
Amaduddin
Khan, Md Shahzad
Abid, Mohammad
Khan, M. S.
Rahisuddin
JOURNAL OF MOLECULAR STRUCTURE, 2020, 1208
[42] Synthesis, Characterization, and DNA Binding Studies of a New Pt(II) Complex Containing the Drug Levetiracetam: Combining Experimental and Computational Methods
Shahabadi, Nahid
Hadidi, Saba
Taherpour, Avat
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2014, 172 (05) : 2436 - 2454
[43] Novel copper nano-complex based on tetraazamacrocyclic backbone: Template synthesis, structural elucidation, cytotoxic, DNA binding and molecular docking studies
Fouad, R.
Shebl, Magdy
Saif, M.
Gamal, S.
JOURNAL OF MOLECULAR STRUCTURE, 2022, 1251
[44] Synthesis of novel calix[4]arene p-benzazole derivatives and investigation of their DNA binding and cleavage activities with molecular docking and experimental studies
Ozkan, Seyda Cigdem
Aksakal, Fatma
Yilmaz, Aydan
RSC ADVANCES, 2020, 10 (63) : 38695 - 38708
[45] Synthesis, Characterization and DNA-Binding Studies of Hydroxyl Functionalized Platinum(II) Salphen Complexes
Shahratul Ain Mohd Sukri
Lee Yook Heng
Nurul Huda Abd Karim
Journal of Fluorescence, 2017, 27 : 1009 - 1023
[46] Synthesis, Characterization and DNA-Binding Studies of Hydroxyl Functionalized Platinum(II) Salphen Complexes
Sukri, Shahratul Ain Mohd
Heng, Lee Yook
Abd Karim, Nurul Huda
JOURNAL OF FLUORESCENCE, 2017, 27 (03) : 1009 - 1023
[47] Design, synthesis, and biological evaluation of novel carbazole aminothiazoles as potential DNA-targeting antimicrobial agents
Addla, Dinesh
Wen, Si-Qi
Gao, Wei-Wei
Maddili, Swetha Kameswari
Zhang, Ling
Zhou, Cheng-He
MEDCHEMCOMM, 2016, 7 (10) : 1988 - 1994
[48] Trifluoromethylated carboline compounds targeting DNA: Synthesis, binding and anti-proliferative effects on human cancer cell lines
Sarkar, Santa
Shmatova, Olga, I
Nenajdenko, Valentine G.
Bhadra, Kakali
BIOORGANIC CHEMISTRY, 2019, 86 : 61 - 79
[49] Head-to-head bis-hairpin polyamide minor groove binders and their conjugates with triplex-forming oligonucleotides:: Studies of interaction with target double-stranded DNA
Halby, Ludovic
Ryabinin, Vladimir A.
Sinyakov, Alexandre N.
Novopashina, Darya S.
Venyaminova, Alya G.
Grokhovsky, Serguei L.
Surovaya, Anna N.
Gursky, Georgy V.
Boutorine, Alexandre S.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2007, 25 (01) : 61 - 76
[50] DNA-Binding properties studies and spectra of a novel Cu(II) complex with a new coumarin derivative
Qi, Gao-fei
Yang, Zheng-yin
Qin, Dong-dong
Wang, Bao-dui
Li, Tian-rong
CHEMICAL & PHARMACEUTICAL BULLETIN, 2008, 56 (04) : 452 - 456

← 1 2 3 4 5 →