Direct Functionalization of Benzoquinolines

被引：3

作者：

Mamane, Victor ^{[1
]}

Louerat, Frederic ^{[1
]}

Fort, Yves ^{[1
]}

机构：

[1] Nancy Univ, Lab SRSMC, CNRS, Equipe Synth Organometall & React,UMR 7565, F-70239 Vandoeuvre Les Nancy, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2010年 / 7卷 / 01期

关键词：

Benzoquinoline; functionalization; lithiation; addition; PYRIDINE N-OXIDES; C-H BONDS; HETEROCYCLIC CHEMISTRY; STRUCTURAL DIVERSITY; LITHIATION; COMPLEXES; ISOQUINOLINE; DERIVATIVES; ARYLATION; LIGANDS;

D O I：

10.2174/157017810790533986

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first direct lithiation of the pyridine ring of benzo[h]- and benzo[f]- quinolines is reported. The method allowed the introduction of different electrophiles (Cl, Br and SPh) in 2-position. Other groups were introduced by direct nucleophilic addition of alkyllithiums allowing further transformations to functional groups such as esters and thiolesters.

引用

页码：90 / 93

页数：4

共 50 条

[41] Pd-Catalyzed Direct and Selective C-H Functionalization: C3-Acetoxylation of Indoles
Liu, Qiang
Li, Gang
Yi, Hong
Wu, Pan
Liu, Jie
Lei, Aiwen
CHEMISTRY-A EUROPEAN JOURNAL, 2011, 17 (08) : 2353 - 2357
[42] Advanced NMR Methods and DFT Calculations on the Regioselective Deprotonation and Functionalization of 1,1′-Methylenebis(3-methylimidazole-2-thione)
Bauer, Mona
Premuzic, Dejan
Thiele, Guenther
Neumueller, Bernhard
Tonner, Ralf
Raya-Baron, Alvaro
Fernandez, Ignacio
Kuzu, Istemi
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2016, (23) : 3756 - 3766
[43] Functionalization of large-pore mesoporous silicas with organosilanes by direct synthesis
Chong, ASM
Zhao, XS
Kustedjo, AT
Qiao, SZ
MICROPOROUS AND MESOPOROUS MATERIALS, 2004, 72 (1-3) : 33 - 42
[44] Direct C-H functionalization of tetrahydro-γ-carbolines at the α-position
Zhang, Yahui
Chen, Yi
Guo, Mei
Sun, Ge
Que, Rongbin
Cui, Ranran
Gao, Yu
Chen, Haijun
NEW JOURNAL OF CHEMISTRY, 2022, 46 (20) : 9511 - 9514
[45] Hypervalent Iodine(III) in Direct Carbon-Hydrogen Bond Functionalization
Narayan, Rishikesh
Manna, Srimanta
Antonchick, Andrey P.
SYNLETT, 2015, 26 (13) : 1785 - 1803
[46] Direct Functionalization of Indoles: Copper-Catalyzed Malonyl Carbenoid Insertions
Johansen, Michael B.
Kerr, Michael A.
ORGANIC LETTERS, 2010, 12 (21) : 4956 - 4959
[47] Direct Functionalization of para-Quinones: A Historical Review and New Perspectives
Jha, Raushan Kumar
Kumar, Sangit
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 27 (27)
[48] A C-H Functionalization Protocol for the Direct Synthesis of Benzobisthiazole Derivatives
Bon, Jennifer L.
Feng, Daijun
Marder, Seth R.
Blakey, Simon B.
JOURNAL OF ORGANIC CHEMISTRY, 2014, 79 (16) : 7766 - 7771
[49] Light-Induced Direct Decarboxylative Functionalization of Aromatic Carboxylic Acids
Tu, Jia-Lin
Shen, Zhengjia
Huang, Binbin
ADVANCED SYNTHESIS & CATALYSIS, 2024, 366 (21) : 4263 - 4273
[50] Palladium-Catalyzed Direct C-H Functionalization of Benzoquinone
Walker, Sarah E.
Jordan-Hore, James A.
Johnson, David G.
Macgregor, Stuart A.
Lee, Ai-Lan
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (50) : 13876 - 13879

← 1 2 3 4 5 →