Direct Functionalization of Benzoquinolines

被引：3

作者：

Mamane, Victor ^{[1
]}

Louerat, Frederic ^{[1
]}

Fort, Yves ^{[1
]}

机构：

[1] Nancy Univ, Lab SRSMC, CNRS, Equipe Synth Organometall & React,UMR 7565, F-70239 Vandoeuvre Les Nancy, France

来源：

LETTERS IN ORGANIC CHEMISTRY | 2010年 / 7卷 / 01期

关键词：

Benzoquinoline; functionalization; lithiation; addition; PYRIDINE N-OXIDES; C-H BONDS; HETEROCYCLIC CHEMISTRY; STRUCTURAL DIVERSITY; LITHIATION; COMPLEXES; ISOQUINOLINE; DERIVATIVES; ARYLATION; LIGANDS;

D O I：

10.2174/157017810790533986

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first direct lithiation of the pyridine ring of benzo[h]- and benzo[f]- quinolines is reported. The method allowed the introduction of different electrophiles (Cl, Br and SPh) in 2-position. Other groups were introduced by direct nucleophilic addition of alkyllithiums allowing further transformations to functional groups such as esters and thiolesters.

引用

页码：90 / 93

页数：4

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