Synthesis, cytotoxicity and structure-activity relationship study of terpyridines

被引：64

作者：

Zhao, Long-Xuan

Sherchan, Jyoti

Park, Jung Ki

Jahng, Yurngdong

Jeong, Byeong-Seon

Jeong, Tae Cheon

Lee, Chong-Soon

Lee, Eung-Seok ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea

[2] Liaoning Univ, Dept Chem, Dalian 116029, Liaoning, Peoples R China

[3] Yeungnam Univ, Dept Biochem, Kyongsan 712749, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2006年 / 29卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

terpyridines; cytotoxicity; topoisomerase I inhibition; antitumor agent; synthesis;

D O I：

10.1007/BF02969297

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For the development of novel antitumor agents, we designed and synthesized terpyridines, and their biological activities were evaluated. Although most of the newly prepared terpyridines showed strong cytotoxicity against several human cancer cell lines, [2,2';6',2"]-terpyridine displayed the most significant cytotoxicity.

引用

收藏

页码：1091 / 1095

页数：5

相关论文

共 18 条

[1] Structure of DNA topoisomerases [J].

Berger, JM .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3) :3-18

[2] Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme [J].

Burden, DA ;

Osheroff, N .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3) :139-154

[3] Oxidation of DNA and RNA by oxoruthenium(IV) metallointercalators: Visualizing the recognition properties of dipyridophenazine by high-resolution electrophoresis [J].

Carter, PJ ;

Cheng, CC ;

Thorp, HH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (04) :632-642

[4]

DONALD L, 1991, TETRAHEDRON LETT, V32, P1999

[5]

Fukuda M, 1996, CANCER RES, V56, P789

[6] METALLOINTERCALATION REAGENTS - 2-HYDROXYETHANETHIOLATO(2,2',2''-TERPYRIDINE)-PLATINUM(II) MONOCATION BINDS STRONGLY TO DNA BY INTERCALATION [J].

JENNETTE, KW ;

LIPPARD, SJ ;

VASSILIADES, GA ;

BAUER, WR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (10) :3839-3843

[7] Novel protein kinase C inhibitors:: α-terthiophene derivatives [J].

Kim, DSHL ;

Ashendel, CL ;

Zhou, Q ;

Chang, CT ;

Lee, ES ;

Chang, CJ .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (19) :2695-2698

[8] NOVEL LUMINESCENT CYCLOMETALATED AND TERPYRIDINE GOLD(III) COMPLEXES AND DNA-BINDING STUDIES [J].

LIU, HQ ;

CHEUNG, TC ;

PENG, SM ;

CHE, CM .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (17) :1787-1788

[9] The design and synthesis of bis-[4′-Azido-2,2′:6′,2"-terpyridine platinum(II)] complexes with rigid and extended linkers for studying the topology of DNA by photoaffinity labeling [J].

Lowe, G ;

Droz, AS ;

Park, JJ ;

Weaver, GW .

BIOORGANIC CHEMISTRY, 1999, 27 (06) :477-486

[10] 4-Picoline-2,2':6',2''-terpyridine-platinum(II) - A potent intercalator of DNA [J].

McCoubrey, A ;

Latham, HC ;

Cook, PR ;

Rodger, A ;

Lowe, G .

FEBS LETTERS, 1996, 380 (1-2) :73-78