Inhibition of bacterial and fungal pathogens by the orphaned drug auranofin

被引：51

作者：

Fuchs, Beth Burgwyn ^{[1
,2
]}

RajaMuthiah, Rajmohan ^{[1
,2
]}

Remondi Souza, Ana Carolina ^{[3
]}

Eatemadpour, Soraya ^{[1
,2
]}

Rossoni, Rodnei Dennis ^{[4
]}

Santos, Daniel Assis ^{[5
]}

Junqueira, Juliana C. ^{[4
]}

Rice, Louis B. ^{[1
,2
]}

Mylonakis, Eleftherios ^{[1
,2
]}

机构：

[1] Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA

[2] Brown Univ, Providence, RI 02903 USA

[3] Univ Fed Sao Paulo, Escola Paulista Med, Sao Paulo, Brazil

[4] Univ Estadual Paulista, UNESP, Dept Biosci & Oral Diag, BR-12245000 Sao Jose Dos Campos, SP, Brazil

[5] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, Belo Horizonte, MG, Brazil

来源：

FUTURE MEDICINAL CHEMISTRY | 2016年 / 8卷 / 02期

关键词：

antimicrobial; auranofin; Bucillus subtilis; Candida albicans; Cryptococcus neoformans; Enterococcus faecalis; Enterococcus faecium; Staphylococcus aureus; THIOREDOXIN REDUCTASE; CRYPTOCOCCUS-NEOFORMANS; CANDIDA-ALBICANS; MANAGEMENT; VIABILITY; MECHANISM; SELENIUM; THIOL;

D O I：

10.4155/fmc.15.182

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Background: We identified auranofin as an antimicrobial compound utilizing a high-throughput screen using a Caenorhabditis elegans-Staphylococcus aureus infection model. Results/methodology: Treatment of infected nematodes with auranofin resulted in a prolonged survival rate of 95%, reached with 0.78 mu g/ml. Further investigation of the antimicrobial activity of auranofin found inhibition against S. aureus, Enterococcus faecium and Enterococcus faecalis. Importantly, the fungal pathogens Cryptococcus neoformans was also effectively inhibited with an MIC at 0.5 mu g/ml. Auranofin appears to target the thioredoxin system. Conclusion: This work provides extensive additional data on the antibacterial effects of auranofin that includes both reference and clinical isolates and reports a novel inhibition of fungal pathogens by this compound.

引用

页码：117 / 132

页数：16

共 40 条

[1] Inhibition of Schistosoma mansoni Thioredoxin-glutathione Reductase by Auranofin STRUCTURAL AND KINETIC ASPECTS [J].