Proportion of goblet cell is associated with malignant potential in invasive mucinous adenocarcinoma of the lung

被引：3

作者：

Oki, Tomonari ^{[1
,2
,3
,4
]}

Aokage, Keiju ^{[2
]}

Ueda, Takuya ^{[1
,2
,3
]}

Sugano, Masato ^{[3
]}

Tane, Kenta ^{[2
]}

Miyoshi, Tomohiro ^{[2
]}

Kojima, Motohiro ^{[1
]}

Fujii, Satoshi ^{[1
]}

Kuwata, Takeshi ^{[3
]}

Ochiai, Atsushi ^{[5
]}

Funai, Kazuhito ^{[4
]}

Tsuboi, Masahiro ^{[2
]}

Ishii, Genichiro ^{[1
]}

机构：

[1] Natl Canc Ctr Hosp East, Exploratory Oncol Res & Clin Trial Ctr, Div Pathol, 6-5-1 Kashiwanoha, Kashiwa, Chiba 2778577, Japan

[2] Natl Canc Ctr Hosp East, Dept Thorac Surg, Kashiwa, Chiba, Japan

[3] Natl Canc Ctr Hosp East, Dept Pathol & Clin Labs, Kashiwa, Chiba, Japan

[4] Hamamatsu Univ, Dept Surg 1, Sch Med, Hamamatsu, Shizuoka, Japan

[5] Natl Canc Ctr Hosp East, Exploratory Oncol Res & Clin Trial Ctr, Kashiwa, Chiba, Japan

来源：

PATHOLOGY INTERNATIONAL | 2019年 / 69卷 / 09期

关键词：

goblet cell proportion; invasive mucinous adenocarcinoma; tumor-associated macrophages; tumor microenvironment; CLINICOPATHOLOGICAL CHARACTERISTICS; TUMOR PROGRESSION; BRONCHIOLOALVEOLAR CARCINOMA; SYSTEMIC THERAPY; CANCER; MACROPHAGES; MARKER; CLASSIFICATION; PODOPLANIN; PROGNOSIS;

D O I：

10.1111/pin.12853

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Invasive mucinous adenocarcinoma (IMA) is a newly classified variant of lung adenocarcinoma. The aim of this study was to examine the correlation between the proportion of goblet cells and the clinicopathological characteristics of IMA. Ninety-nine patients with stage I IMA were included in this study. We estimated prognostic impact of goblet cell proportion. We classified them into two groups: the cases with a high goblet cell proportion (HGP, goblet cell proportion >= 80%) and the cases with a low goblet cell proportion (LGP, goblet cell proportion <= 30%), and compared the expression levels of five cancer progression markers and the number of tumor-promoting stromal cells between the two groups. Univariate and multivariate analysis revealed that the goblet cell proportion was a prognostic factor for recurrence free survival (P < 0.01) and overall survival (P = 0.01). The expression levels of the cancer stem cell-related marker, ALDH-1, and proliferation-related marker, geminin were significantly higher in the LGP group than in the HGP group. CD204+ tumor-associated macrophages were significantly more in the LGP stroma than the HGP stroma. Our current study indicated that the proportion of goblet cells was correlated with the malignant potential in surgically resected IMA.

引用

页码：526 / 535

页数：10

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