Tityus serrulatus Scorpion Venom and Toxins: An Overview

被引：83
作者：
Cologna, Camila T. [1 ]
Marcussi, Silvana [2 ]
Giglio, Jose R. [3 ]
Soares, Andreimar M. [2 ]
Arantes, Eliane C. [1 ]
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14040903 Ribeirao Preto, SP, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
Scorpion; Tityus serrulatus venom; neurotoxins; ion channels; hyaluronidase; proteases; peptides; GATED SODIUM-CHANNELS; ANDROCTONUS-AUSTRALIS HECTOR; CA2+-ACTIVATED K+ CHANNELS; AMINO-ACID-SEQUENCE; SHAKER BK+-CHANNELS; TSTX-V; NA+-CHANNELS; POTASSIUM CHANNELS; HIGH-AFFINITY; BINDING-SITE;
D O I：
10.2174/092986609788923329
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tityus serrulatus is considered the most dangerous scorpion in South America and responsible for most of the fatal cases. This review will focus on Tityus serrulatus scorpion venom (Tsv), its long-chain Na+-channel toxins (NaTx), which include alpha- and beta-neurotoxins, short-chain K+-channel toxins (KTx), hyaluronidase, proteases and other peptides hitherto identified.
引用
收藏
页码：920 / 932
页数：13
相关论文
共 132 条
[31]   Mechanisms underlying the structural alterations of the rat submandibular gland induced by Tityus serrulatus tityustoxin [J].
Clemente, GT ;
Teixeira, MM ;
Freire-Maia, L ;
Rossoni, RB .
TOXICON, 2002, 40 (06) :731-738
[32]   A large number of novel Ergtoxin-like genes and ERG K+-channels blocking peptides from scorpions of the genus Centruroides [J].
Corona, M ;
Gurrola, GB ;
Merino, E ;
Cassulini, RR ;
Valdez-Cruza, NA ;
García, B ;
Ramírez-Domínguez, ME ;
Coronas, FIV ;
Zamudio, FZ ;
Wanke, E ;
Possani, LD .
FEBS LETTERS, 2002, 532 (1-2) :121-126
[33]   Cloning and characterization of the genomic region encoding toxin IV-5 from the scorpion Tityus serrulatus Lutz and Mello [J].
Corona, M ;
Zurita, M ;
Possani, LD ;
Becerril, B .
TOXICON, 1996, 34 (02) :251-256
[34]   Disulfide bridges and blockage of Shaker BK+-channels by another butantoxin peptide purified from the Argentinean scorpion Tityus trivittatus [J].
Coronas, FV ;
de Roodt, AR ;
Olamendi-Portugal, T ;
Zamudio, FZ ;
Batista, CVF ;
Gómez-Lagunas, F ;
Possani, LD .
TOXICON, 2003, 41 (02) :173-179
[35]   Biochemical and histopathological alterations induced in rats by Tityus serrulatus scorpion venom and its major neurotoxin tityustoxin-I [J].
Correa, MM ;
Sampaio, SV ;
Lopes, RA ;
Mancuso, LC ;
Cunha, OAB ;
Franco, JJ ;
Giglio, JR .
TOXICON, 1997, 35 (07) :1053-1067
[36]   THE EFFECTS OF SCORPION-VENOM TOXIN ON THE RELEASE OF AMINO-ACID NEUROTRANSMITTERS FROM CEREBRAL-CORTEX INVIVO AND INVITRO [J].
COUTINHONETTO, J ;
ABDULGHANI, AS ;
NORRIS, PJ ;
THOMAS, AJ ;
BRADFORD, HF .
JOURNAL OF NEUROCHEMISTRY, 1980, 35 (03) :558-565
[37]   Tityustoxin effect on nerve compound action potentials requires extracellular sodium [J].
Cruz, JS ;
Matavel, ACS ;
Leao, HM ;
Moraes-Santos, T ;
Beirao, PSL .
NEUROSCIENCE LETTERS, 2000, 282 (1-2) :25-28
[38]  
Cupo P., 2003, ANIMAIS PECONHENTOS, P198
[39]  
Cupo Palmira, 1994, Revista do Instituto de Medicina Tropical de Sao Paulo, V36, P67, DOI 10.1590/S0036-46651994000100011
[40]   Overview of scorpion toxins specific for Na+ channels and related peptides:: biodiversity, structure-function relationships and evolution [J].
de la Vega, RCR ;
Possani, LD .
TOXICON, 2005, 46 (08) :831-844
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