Tityus serrulatus Scorpion Venom and Toxins: An Overview

被引：83
作者：
Cologna, Camila T. [1 ]
Marcussi, Silvana [2 ]
Giglio, Jose R. [3 ]
Soares, Andreimar M. [2 ]
Arantes, Eliane C. [1 ]
机构：
[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Quim & Fis, BR-14040903 Ribeirao Preto, SP, Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, Dept Anal Clin Toxicol & Bromatol, BR-14040903 Ribeirao Preto, SP, Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14040903 Ribeirao Preto, SP, Brazil
来源：
PROTEIN AND PEPTIDE LETTERS | 2009年 / 16卷 / 08期
基金：
巴西圣保罗研究基金会;
关键词：
Scorpion; Tityus serrulatus venom; neurotoxins; ion channels; hyaluronidase; proteases; peptides; GATED SODIUM-CHANNELS; ANDROCTONUS-AUSTRALIS HECTOR; CA2+-ACTIVATED K+ CHANNELS; AMINO-ACID-SEQUENCE; SHAKER BK+-CHANNELS; TSTX-V; NA+-CHANNELS; POTASSIUM CHANNELS; HIGH-AFFINITY; BINDING-SITE;
D O I：
10.2174/092986609788923329
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tityus serrulatus is considered the most dangerous scorpion in South America and responsible for most of the fatal cases. This review will focus on Tityus serrulatus scorpion venom (Tsv), its long-chain Na+-channel toxins (NaTx), which include alpha- and beta-neurotoxins, short-chain K+-channel toxins (KTx), hyaluronidase, proteases and other peptides hitherto identified.
引用
收藏
页码：920 / 932
页数：13
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