Therapeutic Potentials of A2B Adenosine Receptor Ligands: Current Status and Perspectives

被引：19

作者：

Chandrasekaran, Balakumar ^{[1
]}

Samarneh, Sara ^{[1
]}

Jaber, Abdul Muttaleb Yousef ^{[1
]}

Kassab, Ghadir ^{[1
]}

Agrawal, Nikhil ^{[2
]}

机构：

[1] Philadelphia Univ, Fac Pharm, POB 1, Amman 19392, Jordan

[2] Univ KwaZulu Natal, Coll Hlth Sci, POB 4000, Durban, South Africa

来源：

CURRENT PHARMACEUTICAL DESIGN | 2019年 / 25卷 / 25期

关键词：

A(2B) adenosine receptor; asthma; cancer; diabetes; GIT disorders; G-protein coupled receptors (GPCRs); FUNCTIONAL GASTROINTESTINAL DISORDERS; ACUTE KIDNEY INJURY; BIOLOGICAL EVALUATION; HIGHLY POTENT; A2B RECEPTORS; CANCER-CELLS; ANTAGONIST RADIOLIGAND; SELECTIVE ANTAGONISTS; XANTHINE DERIVATIVES; SIGNALING PROTECTS;

D O I：

10.2174/1381612825666190717105834

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Adenosine receptors (ARs) are classified as A(1), A(2A), A(2B), and A(3) subtypes belong to the superfamily of G-protein coupled receptors (GPCRs). More than 40% of modern medicines act through either activation or inhibition of signaling processes associated with GPCRs. In particular, A(2B) AR signaling pathways are implicated in asthma, inflammation, cancer, ischemic hyperfusion, diabetes mellitus, cardiovascular diseases, gastrointestinal disorders, and kidney disease. Methods: This article reviews different disease segments wherein A(2B) AR is implicated and discusses the potential role of subtype-selective A(2B) AR ligands in the management of such diseases or disorders. All the relevant publications on this topic are reviewed and presented scientifically. Results: This review provides an up-to-date highlight of the recent advances in the development of novel and selective A(2B) AR ligands and their therapeutic role in treating various disease conditions. A special focus has been given to the therapeutic potentials of selective A(2B) AR ligands in the management of airway inflammatory conditions and cancer. Conclusions: This systematic review demonstrates the current status and perspectives of A(2B) AR ligands as therapeutically useful agents that would assist medicinal chemists and pharmacologists in discovering novel and subtype-selective A(2B) AR ligands as potential drug candidates.

引用

页码：2741 / 2771

页数：31

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