Inhibition of vascularization in tumor growth

被引：37
作者：
Scalerandi, M [1 ]
Sansone, BC
机构：
[1] Politecn Torino, Dipartimento Fis, INFM, Turin, Italy
[2] Los Alamos Natl Lab, Los Alamos, NM USA
来源：
PHYSICAL REVIEW LETTERS | 2002年 / 89卷 / 21期
关键词：
D O I：
10.1103/PhysRevLett.89.218101
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The transition to a vascular phase is a prerequisite for fast tumor growth. During the avascular phase, the neoplasm feeds only from the (relatively few) existing nearby blood vessels. During angiogenesis, the number of capillaries surrounding and infiltrating the tumor increases dramatically. A model which includes physical and biological mechanisms of the interactions between the tumor and vascular growth describes the avascular-vascular transition. Numerical results agree with clinical observations and predict the influence of therapies aiming to inhibit the transition.
引用
收藏
页码：218101 / 218101
页数：4
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