The role of SUMO in chromosome segregation

被引：38
作者：
Watts, Felicity Z. [1 ]
机构：
[1] Univ Sussex, Sch Life Sci, Genome Damage & Stabil Ctr, Brighton BN1 9QG, E Sussex, England
来源：
CHROMOSOMA | 2007年 / 116卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1007/s00412-006-0079-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Chromosome segregation is an essential feature of the eukaryotic cell cycle. Efficient chromosome segregation requires the co-ordination of several cellular processes; some of which involve gross rearrangements of the overall structure of the genetic material. Recent advances in the analysis of the role of SUMO (small ubiquitin-like modifier) and in the identification of SUMO-modified targets indicate that sumoylation is likely to have several key roles in regulating chromosome segregation This mini-review summarises the recently published data concerning the role of SUMO in the processes required for efficient chromosome segregation.
引用
收藏
页码：15 / 20
页数：6
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