Raman spectroscopy study of breast disease

被引：38

作者：

Moreno, Marcelo ^{[1
,2
]}

Raniero, Leandro ^{[1
]}

Loschiavo Arisawa, Emilia Angelo ^{[1
]}

do Espirito Santo, Ana Maria ^{[1
]}

Pereira dos Santos, Edson Aparecido ^{[1
]}

Bitar, Renata Andrade ^{[1
]}

Martin, Airton Abrahao ^{[1
]}

机构：

[1] Univ Vale Paraiba, IP&D, Inst Res & Dev, Lab Biomed Vibrat Spect, BR-12244000 Sao Jose Dos Campos, SP, Brazil

[2] Univ Comunitaria Reg Chapeco, Sch Med, BR-89809000 Chapeco, Santa Catarina, Brazil

来源：

THEORETICAL CHEMISTRY ACCOUNTS | 2010年 / 125卷 / 3-6期

基金：

巴西圣保罗研究基金会;

关键词：

Raman spectroscopy; Breast cancer; Principal component analysis; Biochemical analysis; Linear discriminant analysis; Quadratic correlation analysis; DUCTAL CARCINOMA; IN-VIVO; CANCER; SPECTRA; DIAGNOSIS; CYSTEINE; TISSUES;

D O I：

10.1007/s00214-009-0698-6

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The aim of this study was to evaluate the vibrational modes of malignant and benign breast tissues with the following diagnosis: fibroadenoma, invasive ductal carcinoma, ductal carcinoma in situ, and fibrocystic condition. Quadratic discriminate analysis, a multivariate statistical method of analysis, showed 98.5% separation between normal and altered tissue. Significant changes were observed at the lower Raman shift for altered tissue. For a better understanding of the spectral differences, a biochemical interpretation was also performed in terms of the reduction and oxidation processes in the cell environment which could be associated with an inflammatory reaction.

引用

页码：329 / 334

页数：6

共 37 条

[1]

[Anonymous], ADV SPECTROSCOPY

[2] Biochemical analysis of human breast tissues using Fourier-transform Raman spectroscopy [J].

Bitar, Renata Andrade ;

Martinho, Herculano da Silva ;

Tierra-Criollo, Carlos Julio ;

Zambelli Ramalho, Leandra Naira ;

Netto, Mario Mourao ;

Martin, Airton Abrahao .

JOURNAL OF BIOMEDICAL OPTICS, 2006, 11 (05)

[3] Dioxygen activation at mononuclear nonheme iron active sites: Enzymes, models, and intermediates [J].

Costas, M ;

Mehn, MP ;

Jensen, MP ;

Que, L .

CHEMICAL REVIEWS, 2004, 104 (02) :939-986

[4] FT-Raman spectra of the border of infiltrating ductal carcinoma lesions [J].

de Miranda Marzullo, Ana Carolina ;

Neto, Osmar Pinto ;

Bitar, Renata Andrade ;

Martinho, Herculano da Silva ;

Martin, Airton Abrahao .

PHOTOMEDICINE AND LASER SURGERY, 2007, 25 (05) :455-460

[5]

Deng H, 1999, BIOPOLYMERS, V50, P656, DOI 10.1002/(SICI)1097-0282(199911)50:6<656::AID-BIP10>3.0.CO

[6]

2-9

[7] Melatonin is a scavenger of peroxynitrite [J].

Gilad, E ;

Cuzzocrea, S ;

Zingarelli, B ;

Salzman, AL ;

Szabo, C .

LIFE SCIENCES, 1997, 60 (10) :PL169-PL174

[8] Diagnosis of degenerative lesions of supraspinatus rotator cuff tendons by Fourier transform-Raman spectroscopy [J].

Godoy Penteado, Sergio Camargo ;

Fogazza, Bianca Palma ;

Carvalho, Carolina da Silva ;

Loschiavo Arisawa, Emilia Angela ;

Martins, Mario Augusto ;

Martin, Airton Abrahao ;

Martinho, Herculano da Silva .

JOURNAL OF BIOMEDICAL OPTICS, 2008, 13 (01)

[9] In vivo margin assessment during partial mastectomy breast surgery using Raman spectroscopy [J].

Haka, AS ;

Volynskaya, Z ;

Gardecki, JA ;

Nazemi, J ;

Lyons, J ;

Hicks, D ;

Fitzmaurice, M ;

Dasari, RR ;

Crowe, JP ;

Feld, MS .

CANCER RESEARCH, 2006, 66 (06) :3317-3322

[10] Diagnosing breast cancer by using Raman spectroscopy [J].

Haka, AS ;

Shafer-Peltier, KE ;

Fitzmaurice, M ;

Crowe, J ;

Dasari, RR ;

Feld, MS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (35) :12371-12376

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