Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

被引：37

作者：

Dong, Yizhou ^{[1
]}

Shi, Qian ^{[1
]}

Nakagawa-Goto, Kyoko ^{[1
]}

Wu, Pei-Chi ^{[1
]}

Morris-Natschke, Susan L. ^{[1
]}

Brossi, Arnold ^{[1
]}

Bastow, Kenneth F. ^{[2
]}

Lang, Jing-Yu ^{[3
]}

Hung, Mien-Chie ^{[3
,4
,5
]}

Lee, Kuo-Hsiung ^{[1
]}

机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA

[2] Univ N Carolina, UNC Eshelman Sch Pharm, Div Med Chem & Nat Prod, Chapel Hill, NC 27599 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Houston, TX 77030 USA

[4] China Med Univ & Hosp, Ctr Mol Med, Taichung 404, Taiwan

[5] China Med Univ & Hosp, Grad Inst Canc Biol, Taichung 404, Taiwan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 02期

关键词：

6-Phenyl-4H-furo[3,2-c]pyran-4-ones; Neo-tanshinlactone; Breast cancer; BIOLOGICAL EVALUATION; NEO-TANSHINLACTONE; NATURAL-PRODUCTS; ANALOGS; DESIGN;

D O I：

10.1016/j.bmc.2009.11.049

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Phenyl-4H-furo[3,2-c]pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10-13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100-250-fold more potent against SK-BR-3 (ED50 0.28 and 0.44 mu M, respectively) compared with other cancer cell lines tested. In addition, 25 displayed low cytotoxicity against normal breast cell lines 184A1 and MCF10A. Compounds 25 and 27 merit further investigation in our continuing program to generate and develop selective anti-breast cancer agents. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：803 / 808

页数：6

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