Short-chain fatty acids and poly-β-hydroxyalkanoates: (New) Biocontrol agents for a sustainable animal production

被引:133
作者
Defoirdt, Tom [1 ,2 ]
Boon, Nico [3 ]
Sorgeloos, Patrick [1 ,2 ]
Verstraete, Willy [3 ]
Bossier, Peter [1 ,2 ]
机构
[1] Univ Ghent, Lab Aquaculture, B-9000 Ghent, Belgium
[2] Univ Ghent, Artemia Reference Ctr, B-9000 Ghent, Belgium
[3] Univ Ghent, LabMET, B-9000 Ghent, Belgium
关键词
Short-chain fatty acid; Polyhydroxyalkanoate; PHB; Infections; Animal production; FED-BATCH CULTURE; PATHOGENIC VIBRIO-CAMPBELLII; RECOMBINANT ESCHERICHIA-COLI; GNOTOBIOTIC ARTEMIA-FRANCISCANA; IN-VITRO; ORGANIC-ACIDS; BACTERIAL POLYHYDROXYALKANOATES; ALCALIGENES-EUTROPHUS; HYDROXYBUTYRIC ACID; PHB PRODUCTION;
D O I
10.1016/j.biotechadv.2009.04.026
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Because of the risk of antibiotic resistance development, there is a growing awareness that antibiotics should be used more carefully in animal production. However. a decreased use of antibiotics could result in a higher frequency of pathogenic bacteria. which ill Its turn Could lead to a higher incidence of infections Short-chain fatty acids (SCFAs) have long been known to exhibit bacteriostatic activity. These compounds also specifically downregulate virulence factor expression and positively influence the gastrointestinal health of the host As a consequence, there is currently considerable interest in SCFAs as biocontrol agents in animal production Polyhydroxyalkanoates (PHAs) are polymers of beta-hydroxy short-chain fatty acids. Currently. PHAs are applied as replacements for synthetic polymers. These biopolymers can be depolymerised by many different microorganisms that produce extracellular PHA depolymerases. Interestingly. different studies provided some evidence that PHAs can also be degraded upon passage through the gastrointestinal tract of animals and consequently. adding these compounds to the feed might result in biocontrol effects similar to those described for SCFAs. (C) 2009 Elsevier Inc. All rights reserved
引用
收藏
页码:680 / 685
页数:6
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