Protective effect of daidzein against streptozotocin-induced Alzheimer's disease via improving cognitive dysfunction and oxidative stress in rat model

被引：57
作者：
Wei, Jie [1 ]
Yang, Fenggang [1 ]
Gong, Chuanbao [2 ]
Shi, Xingyuan [1 ]
Wang, Guangliang [3 ]
机构：
[1] Dezhou Peoples Hosp, Dept Internal Neurol, 1751 Xinhu Rd, Dezhou 253014, Shandong, Peoples R China
[2] Shandong Mingren Freda Pharmaceut Co Ltd, Jinan, Shandong, Peoples R China
[3] Innosci Res Sdn Bhd, Subang Jaya, Selangor, Malaysia
来源：
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2019年 / 33卷 / 06期
关键词：
Alzheimer disease; daidzein; intracerebroventricular-streptozotocin; locomotor activity; morris water maze test; oxidative stress; MICE;
D O I：
10.1002/jbt.22319
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxidative stress is performing an essential role in developing Alzheimer's disease (AD), and age-related disorder and other neurodegenerative diseases. In existing research, we have aimed at investigating the daidzein (4',7-dihydroxyisoflavone) effect (10 and 20 mg/kg of body weight), as a free radical scavenger and antioxidant in streptozotocin (STZ) infused AD in rat model. Daidzein treatment led to significant improvement in intracerebroventricular- streptozotocin (ICV-STZ)-induced memory and learning impairments that was evaluated by Morris water maze test and spontaneous locomotor activity. It significantly restored the alterations in malondialdehyde, catalase, superoxide dismutase, and reduced glutathione levels. In addition, histopathological observations in cerebral cortex and hippocampal areas confirmed the neuroprotective effect of daidzein. These outcomes provide experimental proof showing preventive effect of daidzein on memory, learning dysfunction and oxidative stress in case of ICV-STZ rats. In conclusion, daidzein offers a potential treatment module for various neurodegenerative disorders with regard to mental deficits like AD.
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页数：7
相关论文
共 37 条
[1]   Antiulcer and antioxidant activities of a new steroid from Morus alba [J].
Ahmad, Aftab ;
Gupta, Gaurav ;
Afzal, Muhammad ;
Kazmi, Imran ;
Anwar, Firoz .
LIFE SCIENCES, 2013, 92 (03) :202-210
[2]   Cancer chemoprevention through dietary flavonoids: what's limiting? [J].
Amawi, Haneen ;
Ashby, Charles R., Jr. ;
Tiwari, Amit K. .
CHINESE JOURNAL OF CANCER, 2017, 36
[3]   Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats [J].
Aras, Adem Bozkurt ;
Guven, Mustafa ;
Akman, Tarik ;
Ozkan, Adile ;
Sen, Halil Murat ;
Duz, Ugur ;
Kalkan, Yildiray ;
Silan, Coskun ;
Cosar, Murat .
NEURAL REGENERATION RESEARCH, 2015, 10 (01) :146-152
[4]   Anti-cancer potential of flavonoids: recent trends and future perspectives [J].
Batra, Priya ;
Sharma, Anil K. .
3 BIOTECH, 2013, 3 (06) :439-459
[5]  
Bhosale Uma A, 2011, Int J Appl Basic Med Res, V1, P104, DOI 10.4103/2229-516X.91154
[6]   Amyloid β-Peptide (1-42)-Induced Oxidative Stress in Alzheimer Disease: Importance in Disease Pathogenesis and Progression [J].
Butterfield, D. Allan ;
Swomley, Aaron M. ;
Sultana, Rukhsana .
ANTIOXIDANTS & REDOX SIGNALING, 2013, 19 (08) :823-835
[7]   Metabolic Dysfunction in Alzheimer's Disease and Related Neurodegenerative Disorders [J].
Cai, Huan ;
Cong, Wei-na ;
Ji, Sunggoan ;
Rothman, Sarah ;
Maudsley, Stuart ;
Martin, Bronwen .
CURRENT ALZHEIMER RESEARCH, 2012, 9 (01) :5-17
[8]   A Non-transgenic Mouse Model (icv-STZ Mouse) of Alzheimer's Disease: Similarities to and Differences from the Transgenic Model (3xTg-AD Mouse) [J].
Chen, Yanxing ;
Liang, Zhihou ;
Blanchard, Julie ;
Dai, Chun-Ling ;
Sun, Shenggang ;
Lee, Moon H. ;
Grundke-Iqbal, Inge ;
Iqbal, Khalid ;
Liu, Fei ;
Gong, Cheng-Xin .
MOLECULAR NEUROBIOLOGY, 2013, 47 (02) :711-725
[9]  
Cui H., 2012, Journal of signal transduction, V2012
[10]   Rutin as a Potent Antioxidant: Implications for Neurodegenerative Disorders [J].
Enogieru, Adaze Bijou ;
Haylett, William ;
Hiss, Donavon Charles ;
Bardien, Soraya ;
Ekpo, Okobi Eko .
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2018, 2018
1234