A comparison of two intravesical bladder instillations for interstitial cystitis/bladder pain syndrome

被引：4

作者：

Keane, J. ^{[1
,2
]}

Young, N. ^{[1
]}

Goh, J. ^{[3
]}

Atherton, M. ^{[4
]}

Yin, J. ^{[5
]}

Moore, K. ^{[6
,7
]}

Hall, P. ^{[8
]}

Higgs, P. ^{[9
]}

Leitch, A. ^{[1
]}

Lee, J. ^{[1
,10
]}

Rosamilia, A. ^{[1
,2
]}

机构：

[1] Monash Hlth, Melbourne, Vic, Australia

[2] Monash Univ, Melbourne, Vic, Australia

[3] Greenslopes Hosp, Greenslopes, Qld, Australia

[4] Wexford Med Ctr, Murdoch, WA, Australia

[5] Hollywood Hosp, Nedlands, WA, Australia

[6] St George Hosp, Kogarah, NSW, Australia

[7] Univ New South Wales, Sydney, NSW, Australia

[8] St Andrews Mem Hosp, Spring Hill, Qld, Australia

[9] Buder Private Hosp, Buderim, Qld, Australia

[10] Vincents Clin, Darlinghurst, NSW, Australia

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 2021年 / 256卷

关键词：

Bladder pain syndrome; Interstitial cystitis; Overactive bladder; iAluRil (R); DMSO; HYALURONIC-ACID; CHONDROITIN SULFATE; THERAPY;

D O I：

10.1016/j.ejogrb.2020.10.060

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Objective: Bladder pain syndrome (BPS) is a chronic pain condition associated with injury to the glycosoaminoglycan (GAG) layer. We aimed to prospectively evaluate iAluRil (R) with multi-centre tertiary urogynaecology collaboration. We hypothesised that iAluRil (R) (a GAG therapy) would demonstrate equivalent symptom, pain and QOL scores compared to DMSO controls. Study Design: iAluRil (R) was administered for 7 instillations over 3 months in 34 women over 6 sites. 18 historical DMSO controls were matched 2:1. At baseline and 3 months post treatment validated questionnaires were collected. Results: Both iAluRil (R) and DMSO were associated with statistically significant improvements in IC/BPS specific questionnaire scores. iAluRil (R) showed statistically significant improvements in pain, symptoms, and QOL. 45 % of iAluRil (R) recipients had a greater than 50 % reduction in pain score as represented by the VAS. DMSO was also effective in improving measures of IC/BPS with statistically significant decreases in ICSI and ICPI. There was no statistically significant difference in the size of the effect between DMSO and iAluRil (R). Conclusions: iAluRil (R) is well tolerated and associated with significant improvements in pain and symptom scores. Almost half of refractory BPS will have a 50 % decrease in pain score at three months post treatment. This effect size is similar to DMSO. (C) 2020 Elsevier B.V. All rights reserved.

引用

页码：230 / 234

页数：5

共 22 条

[1] Examination of the Significant Placebo Effect in the Treatment of Interstitial Cystitis/Bladder Pain Syndrome [J].