Why do we itch?

被引：2
作者：
Lerner, Ethan A. [1 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Dept Dermatol, 149,13th St, Charlestown, MA 02129 USA
来源：
EXPERIMENTAL DERMATOLOGY | 2019年 / 28卷 / 12期
关键词：
barrier; grooming; itch; neuroimmune; pleasure;
D O I：
10.1111/exd.14004
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Why do we have the sensation of itch and the associated scratching response? The conventional explanation is that arthropods and other environmental irritants elicit the sensation of itch that then leads to scratching and removal of the stimulus. This explanation is reasonable yet is too limiting for this fascinating sensory phenomenon and the associated somatic (voluntary) response of scratching. We delve into other explanations here. Some of these explanations fit within current areas of basic and clinical knowledge while others are speculative and may help to frame future discussions and study.
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收藏
页码：1474 / 1475
页数：2
相关论文
共 6 条
  • [1] The pleasurability of scratching an itch: a psychophysical and topographical assessment
    bin Saif, G. A.
    Papoiu, A. D. P.
    Banari, L.
    McGlone, F.
    Kwatra, S. G.
    Chan, Y-H
    Yosipovitch, G.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2012, 166 (05) : 981 - 985
  • [2] Scratching Induces Overactivity in Motor-Related Regions and Reward System in Chronic Itch Patients
    Mochizuki, Hideki
    Papoiu, Alexandru D. P.
    Nattkemper, Leigh A.
    Lin, Andrew C.
    Kraft, Robert A.
    Coghill, Robert C.
    Yosipovitch, Gil
    [J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2015, 135 (11) : 2814 - 2823
  • [3] Are itch and scratching the nausea and vomiting of skin?
    Ostadhadi, Sattar
    Azimi, Ehsan
    Lerner, Ethan A.
    Dehpour, Ahmad-Reza
    [J]. EXPERIMENTAL DERMATOLOGY, 2016, 25 (05) : 340 - 343
  • [4] Papoiu A D P, 2011, Br J Dermatol, V164, P1299, DOI 10.1111/j.1365-2133.2011.10318.x
  • [5] Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice
    Ross, Sarah E.
    Mardinly, Alan R.
    McCord, Alejandra E.
    Zurawski, Jonathan
    Cohen, Sonia
    Jung, Cynthia
    Hu, Linda
    Mok, Stephanie I.
    Shah, Anar
    Savner, Erin M.
    Tolias, Christos
    Corfas, Roman
    Chen, Suzhen
    Inquimbert, Perrine
    Xu, Yi
    McInnes, Roderick R.
    Rice, Frank L.
    Corfas, Gabriel
    Ma, Qiufu
    Woolf, Clifford J.
    Greenberg, Michael E.
    [J]. NEURON, 2010, 65 (06) : 886 - 898
  • [6] Chronic Itch: A Disease in Its Own Right Preface
    Yosipovitch, Gil
    [J]. DERMATOLOGIC CLINICS, 2018, 36 (03) : XV - XVI
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