The necessity to develop drugs against parasitic diseases

被引：0

作者：

Kaiser, A ^{[1
]}

Gottwald, A ^{[1
]}

Wiersch, C ^{[1
]}

Maier, W ^{[1
]}

Seitz, HM ^{[1
]}

机构：

[1] Univ Bonn, Inst Med Parasitol, D-53105 Bonn, Germany

来源：

PHARMAZIE | 2002年 / 57卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This review focuses on the most significant trends in the development of drugs for the treatment of malaria, African sleeping sickness and toxoplasmosis. In the case of malaria, those include new fixed-dose artemisinin combinations, antifolates and new targets in the apicoplast of Plasmodium falciparum. Targets in the treatment of trypanosomiasis are the biosynthesis of glycosylphosphatidylinositol and enzymes incolved in the biosynthesis of trypanothione. Efforts to develop a vaccine against toxoplasmosis are discussed as well.

引用

页码：723 / 728

页数：6

共 32 条

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