Circadian Timing of Food Intake Contributes to Weight Gain

被引:736
作者
Arble, Deanna M. [1 ]
Bass, Joseph [1 ,2 ]
Laposky, Aaron D. [1 ]
Vitaterna, Martha H. [1 ]
Turek, Fred W. [1 ]
机构
[1] Northwestern Univ, Ctr Sleep & Circadian Biol, Evanston, IL 60208 USA
[2] Northwestern Univ, Dept Med, Feinberg Sch Med, Evanston, IL USA
关键词
METABOLIC SYNDROME; OBESITY; SLEEP; ASSOCIATION; PATTERNS; RHYTHMS;
D O I
10.1038/oby.2009.264
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Studies of body weight regulation have focused almost entirely on caloric intake and energy expenditure. However, a number of recent studies in animals linking energy regulation and the circadian clock at the molecular, physiological, and behavioral levels raise the possibility that the timing of food intake itself may play a significant role in weight gain. The present study focused on the role of the circadian phase of food consumption in weight gain. We provide evidence that nocturnal mice fed a high-fat diet only during the 12-h light phase gain significantly more weight than mice fed only during the 12-h dark phase. A better understanding of the role of the circadian system for weight gain could have important implications for developing new therapeutic strategies for combating the obesity epidemic facing the human population today.
引用
收藏
页码:2100 / 2102
页数:3
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