Evaluation of in vivo antineoplastic effects of rapamycin in patients with chemotherapy-refractory AML

被引：23

作者：

Boehm, Alexandra ^{[1
,2
]}

Mayerhofer, Matthias ^{[3
]}

Herndlhofer, Susanne ^{[1
]}

Knoebl, Paul ^{[1
]}

Sillaber, Christian ^{[1
]}

Sperr, Wolfgang R. ^{[1
]}

Jaeger, Ulrich ^{[1
]}

Valent, Peter ^{[1
]}

机构：

[1] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Austria

[2] Med Univ Vienna, Bone Marrow Transplantat Unit, A-1090 Vienna, Austria

[3] Med Univ Vienna, Clin Inst Med & Chem Lab Diagnost, A-1090 Vienna, Austria

来源：

EUROPEAN JOURNAL OF INTERNAL MEDICINE | 2009年 / 20卷 / 08期

关键词：

AML; Chemotherapy resistance; Rapamycin; mTOR; ACUTE MYELOID-LEUKEMIA; STEM-CELL TRANSPLANTATION; MAMMALIAN TARGET; HEMATOLOGIC MALIGNANCIES; ANTILEUKEMIC ACTIVITY; DOSE CYTARABINE; CANCER-THERAPY; MTOR; INHIBITOR; GROWTH;

D O I：

10.1016/j.ejim.2009.09.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The mammalian target of rapamycin (mTOR) has recently been identified as a potential target in acute myeloid leukemia (AML). Methods: We treated 5 patients with chemotherapy-refractory AML with the mTOR-inhibitor rapamycin at 2 mg per os daily for 14 days, with dose adjustment allowed to reach a target serum rapamycin concentration of 1020 ng/mL. Four of five patients received additional hydroxyurea at constant dose during treatment with rapamycin. Results: Two patients achieved a leukocyte response, in one of them, a prolonged response was seen. In the other patients, blast counts remained stable or increased during rapamycin therapy. We did not observe severe hematologic or non-hematologic side effects of rapamycin. Conclusion: Rapamycin at 2 mg per day acts mildly cytoreductive in a subgroup of patients with refractory AML. Higher doses and drug combinations may be required to obtain long lasting anti-leukemic effects in these patients. (C) 2009 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

引用

页码：775 / 778

页数：4

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