The relationship between obstructive sleep apnea and diabetic retinopathy in type 2 diabetes patients, Zagazig University Hospitals, Egypt

被引:9
作者
Embarak, Sameh [1 ]
Abbas, Ahmad [1 ]
Al-Nashar, Haitham Y. [2 ]
Farag, Salama E. [3 ]
机构
[1] Zagazig Univ, Dept Chest, Fac Med, Zagazig, Nigeria
[2] Zagazig Univ, Dept Ophthalmol, Fac Med, Zagazig, Nigeria
[3] Zagazig Univ, Dept Internal Med, Fac Med, Zagazig, Nigeria
来源
EGYPTIAN JOURNAL OF CHEST DISEASES AND TUBERCULOSIS | 2019年 / 68卷 / 03期
关键词
diabetic retinopathy; maculopathy; obstructive sleep apnea; type 2 diabetes mellitus; ENDOTHELIAL GROWTH-FACTOR; OXIDATIVE STRESS; SERUM-LEVELS; PREVALENCE; MEN; INFLAMMATION; DYSFUNCTION; IMPAIRMENT; MANAGEMENT; PRESSURE;
D O I
10.4103/ejcdt.ejcdt_160_18
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Background and objective Obstructive sleep apnea (OSA) and type 2 diabetes mellitus (T2DM) commonly coexist. Both could be associated with a number of pathophysiological derangements involved in the development of diabetic retinopathy (DR). So, the aim of this study was to assess the possible association between OSA and DR. Patients and methods This is a cross-sectional observational study that was conducted on patients with T2DM. Two-field 45 degrees-digital retinal images for each eye were used to evaluate DR and graded according to the English National Screening Program guidelines. OSA was evaluated on the basis of an inpatient overnight sleep study (polysomnography) using a computerized polysomnogram device. Results This work recruited 110 patients. OSA was observed in 60% (66 patients). OSA was found to be independently associated with both advanced DR [preprolifrative (R2) or proliferative (R3)] (odds ratio=6.29; 95% confidence interval: 1.08-6.65; P=0.04) and maculopathy (odds ratio=12.92; 95% confidence interval: 3.97-4.79; P<0.001). Moreover, OSA severity was directly related to DR grade (r=0.5, P<0.001). Conclusion OSA was independently associated with advanced DR and maculopathy in T2DM patients. Moreover, severity of OSA was directly related to DR grade.
引用
收藏
页码:290 / 295
页数:6
相关论文
共 41 条
[21]   Oxidative Stress-A Unifying Paradigm in Obstructive Sleep Apnea and Comorbidities [J].
Lavie, Lena .
PROGRESS IN CARDIOVASCULAR DISEASES, 2009, 51 (04) :303-312
[22]   Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss [J].
Lee, Ryan ;
Wong, Tien Y. ;
Sabanayagam, Charumathi .
EYE AND VISION, 2015, 2
[23]   Lipids and diabetic retinopathy [J].
Lim, Laurence S. ;
Wong, Tien Y. .
EXPERT OPINION ON BIOLOGICAL THERAPY, 2012, 12 (01) :93-105
[24]  
Mahmood K, 2009, J CLIN SLEEP MED, V5, P215
[25]  
Punjabi Naresh M, 2008, Proc Am Thorac Soc, V5, P136, DOI 10.1513/pats.200709-155MG
[26]  
Resnikoff S, 2004, B WORLD HEALTH ORGAN, V82, P844
[27]   Obstructive Sleep Apnea and Diabetes A State of the Art Review [J].
Reutrakul, Sirimon ;
Mokhlesi, Babak .
CHEST, 2017, 152 (05) :1070-1086
[28]   Serum levels of vascular endothelial growth factor are elevated in patients with obstructive sleep apnea and severe nighttime hypoxia [J].
Schulz, R ;
Hummel, C ;
Heinemann, S ;
Seeger, W ;
Grimminger, F .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2002, 165 (01) :67-70
[29]   Nocturnal Intermittent Serious Hypoxia and Reoxygenation in Proliferative Diabetic Retinopathy Cases [J].
Shiba, Tomoaki ;
Maeno, Takatoshi ;
Saishin, Yoshitsugu ;
Hori, Yuichi ;
Takahashi, Mao .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2010, 149 (06) :959-963
[30]   Endothelial dysfunction and low-grade inflammation and the progression of retinopathy in Type 2 diabetes [J].
Spijkerman, A. M. W. ;
Gall, M.-A. ;
Tarnow, L. ;
Twisk, J. W. R. ;
Lauritzen, E. ;
Lund-Andersen, H. ;
Emeis, J. ;
Parving, H.-H. ;
Stehouwer, C. D. A. .
DIABETIC MEDICINE, 2007, 24 (09) :969-976