Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

被引：15
作者：
Ahtiainen, Petteri
Rulli, Susana
Pakarainen, Tomi
Zhang, Fu-Ping
Poutanen, Matti
Huhtaniemi, Ilpo
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London W12 0NN, England
[2] Univ Turku, Dept Physiol, FIN-20520 Turku, Finland
[3] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt, RA-1428 Buenos Aires, DF, Argentina
[4] Univ Helsinki, Biomedicum, Dept Physiol, FIN-00014 Helsinki, Finland
来源：
MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2007年 / 260卷
关键词：
luteinising hormone; luteinising hormone receptor; transgenic; knockout; ovary; testis; pituitary gland; tumorigenesis; luteoma; prolactinoma;
D O I：
10.1016/j.mce.2005.11.047
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta Subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic Stimulus. The purpose of this review is to summarise the key findings on these two genetically modified Mouse models. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：255 / 263
页数：9
相关论文
共 52 条
[1]   The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction [J].
Abel, MH ;
Wootton, AN ;
Wilkins, V ;
Huhtaniemi, I ;
Knight, PG ;
Charlton, HM .
ENDOCRINOLOGY, 2000, 141 (05) :1795-1803
[2]   Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice [J].
Ahtiainen, P ;
Rulli, SB ;
Shariatmadari, R ;
Pelliniemi, LJ ;
Toppari, J ;
Poutanen, M ;
Huhtaniemi, IT .
ONCOGENE, 2005, 24 (49) :7301-7309
[3]   A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions [J].
Allan, CM ;
Haywood, M ;
Swaraj, S ;
Spaliviero, J ;
Koch, A ;
Jimenez, M ;
Poutanen, M ;
Levallet, J ;
Huhtaniemi, I ;
Illingworth, P ;
Handelsman, DJ .
ENDOCRINOLOGY, 2001, 142 (06) :2213-2220
[4]   Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems [J].
Apaja, PM ;
Harju, KT ;
Aatsinki, JT ;
Petäjä-Repo, UE ;
Rajaniemi, HJ .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (03) :1899-1906
[5]   Orthotopic transplantation of LH receptor knockout and wild-type ovaries [J].
Chudgar, D ;
Lei, ZM ;
Rao, CV .
LIFE SCIENCES, 2005, 77 (21) :2656-2662
[6]   Understanding ovarian hyperstimulation syndrome [J].
Delbaere, A ;
Smits, G ;
De Leener, A ;
Costagliola, S ;
Vassart, G .
ENDOCRINE, 2005, 26 (03) :285-289
[7]   Impairing follicle-stimulating hormone (FSH) signaling in vivo:: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance [J].
Dierich, A ;
Sairam, MR ;
Monaco, L ;
Fimia, GM ;
Gansmuller, A ;
LeMeur, M ;
Sassone-Corsi, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) :13612-13617
[8]   Vasoactive intestinal peptide is an important endocrine regulatory factor of fetal rat testicular steroidogenesis [J].
El-Gehani, F ;
Tena-Sempere, M ;
Huhtaniemi, I .
ENDOCRINOLOGY, 1998, 139 (04) :1474-1480
[9]   Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis [J].
El-Gehani, F ;
Tena-Sempere, M ;
Huhtaniemi, I .
BIOLOGY OF REPRODUCTION, 2000, 63 (05) :1482-1489
[10]   Natriuretic peptides stimulate steroidogenesis in the fetal rat testis [J].
El-Gehani, F ;
Tena-Sempere, M ;
Ruskoaho, H ;
Huhtaniemi, I .
BIOLOGY OF REPRODUCTION, 2001, 65 (02) :595-600
123456