Phenotypic characterisation of mice with exaggerated and missing LH/hCG action

被引：14

作者：

Ahtiainen, Petteri

Rulli, Susana

Pakarainen, Tomi

Zhang, Fu-Ping

Poutanen, Matti

Huhtaniemi, Ilpo

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, London W12 0NN, England

[2] Univ Turku, Dept Physiol, FIN-20520 Turku, Finland

[3] Consejo Nacl Invest Cient & Tecn, Inst Biol & Med Expt, RA-1428 Buenos Aires, DF, Argentina

[4] Univ Helsinki, Biomedicum, Dept Physiol, FIN-00014 Helsinki, Finland

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2007年 / 260卷

关键词：

luteinising hormone; luteinising hormone receptor; transgenic; knockout; ovary; testis; pituitary gland; tumorigenesis; luteoma; prolactinoma;

D O I：

10.1016/j.mce.2005.11.047

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In order to study the physiology and pathophysiology of gonadotrophin action, we have produced transgenic (TG) mice overexpressing human chorionic gonadotrophin (hCG) alpha and beta Subunits (hCG+ mice) and knockout (KO) mice for the luteinising hormone receptor (LHR; LuRKO mice). The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function, but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic Stimulus. The purpose of this review is to summarise the key findings on these two genetically modified Mouse models. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

引用

页码：255 / 263

页数：9

共 52 条

[1] The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction
Abel, MH
Wootton, AN
Wilkins, V
Huhtaniemi, I
Knight, PG
Charlton, HM
[J]. ENDOCRINOLOGY, 2000, 141 (05) : 1795 - 1803
[2] Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice
Ahtiainen, P
Rulli, SB
Shariatmadari, R
Pelliniemi, LJ
Toppari, J
Poutanen, M
Huhtaniemi, IT
[J]. ONCOGENE, 2005, 24 (49) : 7301 - 7309
[3] A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions
Allan, CM
Haywood, M
Swaraj, S
Spaliviero, J
Koch, A
Jimenez, M
Poutanen, M
Levallet, J
Huhtaniemi, I
Illingworth, P
Handelsman, DJ
[J]. ENDOCRINOLOGY, 2001, 142 (06) : 2213 - 2220
[4] Identification and structural characterization of the neuronal luteinizing hormone receptor associated with sensory systems
Apaja, PM
Harju, KT
Aatsinki, JT
Petäjä-Repo, UE
Rajaniemi, HJ
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (03) : 1899 - 1906
[5] Orthotopic transplantation of LH receptor knockout and wild-type ovaries
Chudgar, D
Lei, ZM
Rao, CV
[J]. LIFE SCIENCES, 2005, 77 (21) : 2656 - 2662
[6] Understanding ovarian hyperstimulation syndrome
Delbaere, A
Smits, G
De Leener, A
Costagliola, S
Vassart, G
[J]. ENDOCRINE, 2005, 26 (03) : 285 - 289
[7] Impairing follicle-stimulating hormone (FSH) signaling in vivo:: Targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance
Dierich, A
Sairam, MR
Monaco, L
Fimia, GM
Gansmuller, A
LeMeur, M
Sassone-Corsi, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13612 - 13617
[8] Vasoactive intestinal peptide is an important endocrine regulatory factor of fetal rat testicular steroidogenesis
El-Gehani, F
Tena-Sempere, M
Huhtaniemi, I
[J]. ENDOCRINOLOGY, 1998, 139 (04) : 1474 - 1480
[9] Evidence that pituitary adenylate cyclase-activating polypeptide is a potent regulator of fetal rat testicular steroidogenesis
El-Gehani, F
Tena-Sempere, M
Huhtaniemi, I
[J]. BIOLOGY OF REPRODUCTION, 2000, 63 (05) : 1482 - 1489
[10] Natriuretic peptides stimulate steroidogenesis in the fetal rat testis
El-Gehani, F
Tena-Sempere, M
Ruskoaho, H
Huhtaniemi, I
[J]. BIOLOGY OF REPRODUCTION, 2001, 65 (02) : 595 - 600

← 1 2 3 4 5 6 →