Synthesis and cytotoxic activity of alkylidene- and alkyl-substituted camptothecins.

被引:5
作者
Candiani, I [1 ]
Bedeschi, A [1 ]
Cabri, W [1 ]
Zarini, F [1 ]
Visentin, G [1 ]
Capolongo, L [1 ]
Geroni, C [1 ]
Ciomei, M [1 ]
机构
[1] PHARMACIA & UPJOHN INC,I-20014 NERVIANO,MI,ITALY
关键词
D O I
10.1016/S0960-894X(97)00105-4
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A new family of camptothecin derivatives is described. Their synthesis, in vitro cytotoxicity, and topoisomerase I inhibition is reported. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:847 / 850
页数:4
相关论文
共 16 条
[11]  
JOHNSON R K, 1989, Proceedings of the American Association for Cancer Research Annual Meeting, V30, P623
[12]  
KINSBURY WD, 1991, J MED CHEM, V34, P98
[13]  
SAWADA S, 1991, CHEM PHARM BULL, V39, P3183
[14]   THE CURRENT STATUS OF CAMPTOTHECIN ANALOGS AS ANTITUMOR AGENTS [J].
SLICHENMYER, WJ ;
ROWINSKY, EK ;
DONEHOWER, RC ;
KAUFMANN, SH .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (04) :271-291
[15]   PLANT ANTITUMOR AGENTS .I. ISOLATION AND STRUCTURE OF CAMPTOTHECIN A NOVEL ALKALOIDAL LEUKEMIA AND TUMOR INHIBITOR FROM CAMPTOTHECA ACUMINATA [J].
WALL, ME ;
WANI, MC ;
COOK, CE ;
PALMER, KH ;
MCPHAIL, AT ;
SIM, GA .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1966, 88 (16) :3888-3890
[16]   PLANT ANTITUMOR AGENTS .23. SYNTHESIS AND ANTILEUKEMIC ACTIVITY OF CAMPTOTHECIN ANALOGS [J].
WANI, MC ;
NICHOLAS, AW ;
WALL, ME .
JOURNAL OF MEDICINAL CHEMISTRY, 1986, 29 (11) :2358-2363