Polymorphisms of transforming growth factor-β1 and transforming growth factor-β1 type II receptor genes are associated with acute graft-versus-host disease in children with HLA-matched sibling bone marrow transplantation

被引:37
作者
Hattori, H
Matsuzaki, A
Suminoe, A
Ihara, K
Nagatoshi, Y
Sakata, N
Kawa, K
Okamura, J
Hara, T
机构
[1] Kyushu Natl Canc Ctr, Inst Clin Res, Minami Ku, Fukuoka 8111395, Japan
[2] Kyushu Univ, Grad Sch Med Sci, Dept Pediat, Fukuoka, Japan
[3] Fukuoka Univ, Sch Hlth Sci, Div Child Hlth, Fukuoka, Japan
[4] Kyushu Natl Canc Ctr, Paediat Sect, Fukuoka, Japan
[5] Osaka Med Ctr, Dept Pediat, Osaka, Japan
[6] Res Inst Maternal & Child Hlth, Osaka, Japan
关键词
TGF-beta; 1; TGF-beta 1 type II receptor; GVHD; cytokine; polymorphism;
D O I
10.1038/sj.bmt.1703684
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
The aim of this study was to determine whether the gene polymorphisms of Th1/Th2 and immunoregulatory cytokines were associated with aGVHD in Japanese children receiving allogeneic bone marrow transplantation (allo BMT). We investigated polymorphisms of genes encoding interleukin (IL)-4, IL-4 receptor (IL-4 R), IL-10, transforming growth factor (TGF)-beta1, TGF-beta1 type 11 receptor (TGF-beta1 RII), interferon (IFN)-gamma, IFN-gamma type 2 receptor (IFN-gamma R2), and IFN regulatory factor (IRF)-1. Sixty-seven patients were treated with alloBMT from HLA-identical siblings, and aGVHD was observed in 38. TGF-beta1 codon 10 leucine (Leu) /proline (Pro) polymorphism in donors was associated with the development of aGVHD. Patients having donors with the Pro allele had aGVHD more frequently than those without Pro allele (30/45 vs 8/20, odds ratio = 3.00; P = 0.04). TGF-beta1 RII 1167 C/T polymorphism in recipients was also associated with the development of aGVHD. The incidence was significantly higher in recipients with T allele than in those without T allele (21/27 vs 16/35, odds ratio = 4.16; P = 0.01). In conclusion, genetic backgrounds of TGF-beta1 and TGF-beta1 RII may be involved in the development of aGVHD in HLA-matched sibling BMT in Japanese children.
引用
收藏
页码:665 / 671
页数:7
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