Telocytes heterogeneity: From cellular morphology to functional evidence

被引:66
作者
Cretoiu, Dragos [1 ,2 ]
Radu, Beatrice Mihaela [3 ,4 ]
Banciu, Adela [4 ]
Banciu, Daniel Dumitru [4 ]
Cretoiu, Sanda Maria [1 ,2 ]
机构
[1] Carol Davila Univ Med & Pharm, Div Cellular & Mol Biol & Histol, Bucharest 050474, Romania
[2] Victor Babes Natl Inst Pathol, Bucharest 050096, Romania
[3] Univ Verona, Dept Neurosci Biomed & Movement Sci, I-37134 Verona, Italy
[4] Univ Bucharest, Dept Anat Anim Physiol & Biophys, Fac Biol, Bucharest 050095, Romania
关键词
Telocytes; Stem cells; Immunophenotype heterogeneity; Regenerative medicine; Cancer; CAJAL-LIKE-CELLS; MESENCHYMAL STEM-CELLS; IDIOPATHIC PULMONARY-FIBROSIS; HUMAN LUNG TELOCYTES; INTERSTITIAL-CELLS; ELECTRON-MICROSCOPE; CARDIAC TELOCYTES; ENDOTHELIAL-CELLS; CD34+STROMAL CELLS/TELOCYTES; MYOCARDIAL TELOCYTES;
D O I
10.1016/j.semcdb.2016.08.023
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Telocytes (TCs), located ubiquitously in the internal organs of vertebrates, are a heterogeneous, recently described, cell population of the stromal space. Characterized by lengthy cytoplasmic extensions that can reach tens of microns and are called telopodes (Tps), TCs are difficult to see using conventional microscopes. It was the electron microscopy which led to their first identification and Popescu's team the first responsible for the reconstructions indicating TCs 'organization' in a three-dimensional (3D) network that is believed to be accountable for the complex roles of TCs. Gradually, it became increasingly evident that TCs are difficult to characterize in terms of immunophenotype and that their phenotype is different depending on the location and needs of the tissue at one time. This review discusses the growing body of evidence accumulated since TCs were discovered and highlights how the complex interplay between TCs and stem cells might be of importance for tissue engineering and regenerative medicine. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:26 / 39
页数:14
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