PTS2 co-receptors: Diverse proteins with common features

被引：76

作者：

Schliebs, Wolfgang ^{[1
]}

Kunau, Wolf-H. ^{[1
]}

机构：

[1] Ruhr Univ Bochum, Inst Physiol Chem, Abt Systembiochem, D-44780 Bochum, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 12期

关键词：

peroxisome; protein import; PTS2-receptor; Pex5p; co-receptor;

D O I：

10.1016/j.bbamcr.2006.08.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

One feature of the PTS2 import pathway is the separation of the roles of the PTS receptor between two proteins. Pex7p alone is insufficient to act as the receptor for the import cycle for peroxisomal matrix proteins. In all cases, Pex7p needs a PTS2 co-receptor to form an import-competent PTS2 receptor complex together with the PTS2 cargo. We provide an overview of the proteins that have been identified as PTS2 co-receptors and discuss their proposed functions. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：1605 / 1612

页数：8

共 36 条

[1] Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways [J].

Albertini, M ;

Rehling, P ;

Erdmann, R ;

Girzalsky, W ;

Kiel, JAKW ;

Veenhuis, M ;

Kunau, WH .

CELL, 1997, 89 (01) :83-92

[2] An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes [J].

Braverman, N ;

Dodt, G ;

Gould, SJ ;

Valle, D .

HUMAN MOLECULAR GENETICS, 1998, 7 (08) :1195-1205

[3] Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei [J].

Choe, J ;

Moyersoen, J ;

Roach, C ;

Carter, TL ;

Fan, E ;

Michels, PAM ;

Hol, WGJ .

BIOCHEMISTRY, 2003, 42 (37) :10915-10922

[4] The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome [J].

Dietrich, FS ;

Voegeli, S ;

Brachat, S ;

Lerch, A ;

Gates, K ;

Steiner, S ;

Mohr, C ;

Pöhlmann, R ;

Luedi, P ;

Choi, SD ;

Wing, RA ;

Flavier, A ;

Gaffney, TD ;

Phillippsen, P .

SCIENCE, 2004, 304 (5668) :304-307

[5] Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p [J].

Dodt, G ;

Warren, D ;

Becker, E ;

Rehling, P ;

Gould, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (45) :41769-41781

[6] Yarrowia lipolytica Pex20p, Saccharomyces cerevisiae Pex18p/Pex21p and mammalian Pex5pL fulfil a common function in the early steps of the peroxisomal PTS2 import pathway [J].

Einwächter, H ;

Sowinski, S ;

Kunau, WH ;

Schliebs, W .

EMBO REPORTS, 2001, 2 (11) :1035-1039

[7] A mobile PTS2 receptor for peroxisomal protein import in Pichia pastoris [J].

Elgersma, Y ;

Elgersma-Hooisma, M ;

Wenzel, T ;

McCaffery, JM ;

Farquhar, MG ;

Subramani, S .

JOURNAL OF CELL BIOLOGY, 1998, 140 (04) :807-820

[8] Mutational analyses of a type 2 peroxisomal targeting signal that is capable of directing oligomeric protein import into tobacco BY-2 glyoxysomes [J].

Flynn, CR ;

Mullen, RT ;

Trelease, RN .

PLANT JOURNAL, 1998, 16 (06) :709-720

[9] Involvement of Pex13p in Pex14p localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes [J].

Girzalsky, W ;

Rehling, P ;

Stein, K ;

Kipper, J ;

Blank, L ;

Kunau, WH ;

Erdmann, R .

JOURNAL OF CELL BIOLOGY, 1999, 144 (06) :1151-1162

[10] Insertion of Pex5p into the peroxisomal membrane is cargo protein-dependent [J].

Gouveia, AM ;

Guimaraes, CP ;

Oliveira, ME ;

Sá-Miranda, C ;

Azevedo, JE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (07) :4389-4392

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