Mitochondria are the powerhouses of immunity

被引：816

作者：

Mills, Evanna L. ^{[1
]}

Kelly, Beth ^{[2
]}

O'Neill, Luke A. J. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin, Ireland

[2] Max Planck Inst Immunobiol & Epigenet, Dept Immunometab, Freiburg, Germany

来源：

NATURE IMMUNOLOGY | 2017年 / 18卷 / 05期

基金：

爱尔兰科学基金会; 英国惠康基金;

关键词：

T-CELL-ACTIVATION; NLRP3 INFLAMMASOME ACTIVATION; SPARE RESPIRATORY CAPACITY; ONE-CARBON METABOLISM; FATTY-ACID OXIDATION; MACROPHAGE POLARIZATION; COMPLEX-I; SUCCINATE-DEHYDROGENASE; SIGNAL-TRANSDUCTION; AEROBIC GLYCOLYSIS;

D O I：

10.1038/ni.3704

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent evidence indicates that mitochondria lie at the heart of immunity. Mitochondrial DNA acts as a danger-associated molecular pattern (DAMP), and the mitochondrial outer membrane is a platform for signaling molecules such as MAVS in RIG-I signaling, and for the NLRP3 inflammasome. Mitochondrial biogenesis, fusion and fission have roles in aspects of immune-cell activation. Most important, Krebs cycle intermediates such as succinate, fumarate and citrate engage in processes related to immunity and inflammation, in both innate and adaptive immune cells. These discoveries are revealing mitochondrial targets that could potentially be exploited for therapeutic gain in inflammation and cancer.

引用

页码：488 / 498

页数：11

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